Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421268 | 0.86 | MAPT (0.60) | L3MBTL1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL5569675 | 0.83 | MAPT (0.57) | L3MBTL1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL7425441 | 0.77 | L3MBTL1 (0.60) | L3MBTL1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL16435278 | 0.75 | NPC1 (0.66) | L3MBTL1RAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL31261581 | 0.74 | NPC1 (0.48) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL2271210 | 0.74 | SMN1; SMN2 (0.54) | RAB9ANPC1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL7426351 | 0.73 | L3MBTL1 (0.49) | L3MBTL1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL7430617 | 0.73 | L3MBTL1 (0.49) | L3MBTL1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL16067423 | 0.73 | L3MBTL1 (0.72) | L3MBTL1RAB9ANPC1SMN1; SMN2MAPK1 | |
| SCHEMBL7427868 | 0.73 | L3MBTL1 (0.51) | L3MBTL1RAB9ANPC1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |