Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.50 |
| ▸ | RELA | Q04206 | 3/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427868 | 0.82 | L3MBTL1 (0.51) | L3MBTL1SMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL7421268 | 0.81 | MAPT (0.60) | L3MBTL1SMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL16067423 | 0.80 | L3MBTL1 (0.72) | L3MBTL1SMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL1353440 | 0.79 | L3MBTL1 (0.77) | L3MBTL1SMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL8934807 | 0.77 | RAB9A (0.74) | L3MBTL1SMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL13130238 | 0.77 | L3MBTL1 (1.00) | L3MBTL1SMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL7422357 | 0.77 | L3MBTL1 (0.51) | L3MBTL1SMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL7422180 | 0.76 | LMNA (0.64) | L3MBTL1SMN1; SMN2RAB9ATP53NPC1 | |
| SCHEMBL1353609 | 0.76 | CA12 (0.62) | L3MBTL1RAB9ANPC1LMNAHTT | |
| SCHEMBL29626126 | 0.75 | ALDH1A1 (0.79) | SMN1; SMN2RAB9ANPC1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |