Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422383 | 1.00 | ATM (0.38) | ATMHPGDKDM4EALDH1A1SIRT1 | |
| SCHEMBL2971408 | 0.88 | ATM (0.41) | ATMHPGDKDM4EALDH1A1SIRT1 | |
| SCHEMBL29696802 | 0.88 | ATM (0.41) | ATMHPGDKDM4EALDH1A1SIRT1 | |
| SCHEMBL4410965 | 0.88 | ATM (0.41) | ATMHPGDKDM4EALDH1A1SIRT1 | |
| Hydrochloric Acid SCHEMBL19744196 | 0.87 | ATM (0.40) | ATMHPGDKDM4EALDH1A1SIRT1 | |
| SCHEMBL9319851 | 0.87 | HPGD (0.37) | HPGDKDM4EALDH1A1CYP2C9TSHR | |
| SCHEMBL9319861 | 0.87 | HPGD (0.37) | HPGDKDM4EALDH1A1CYP2C9TSHR | |
| SCHEMBL11551373 | 0.77 | KDM4E (0.30) | HPGDKDM4EALDH1A1 | |
| SCHEMBL11556600 | 0.74 | MAOA (0.32) | HPGDKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL28806661 | 0.74 | KDM4E (0.40) | ATMHPGDKDM4EALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5288731-A | Antiemetics, antiserotonine agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-02-22 | — | — | US | disclosed |
| WO-1992009284-A1 | 2,6-METHANO-2H-1-BENZOXOCINCARBOXAMIDES AS 5-HT3-ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1992-06-11 | — | — | WO | disclosed |