Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | PNP | P00491 | 4/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422631 | 0.88 | PNP (0.48) | PDE5APDE3BPDE3APNPPDPK1 | |
| SCHEMBL670236 | 0.73 | PDPK1 (0.46) | PNPPDPK1HPGDKDM4ERXFP1 | |
| SCHEMBL6643757 | 0.71 | PNP (0.56) | PNP | |
| SCHEMBL13691975 | 0.66 | PNP (0.62) | PNP | |
| SCHEMBL4762365 | 0.66 | ALDH1A1 (0.38) | PDPK1HPGDRAB9APARP1 | |
| SCHEMBL18521204 | 0.66 | PDPK1 (0.49) | PNPPDPK1KDM4AKDM4BKDM5C | |
| SCHEMBL1149887 | 0.65 | PDE5A (0.52) | PDE5APDE3BPDE3AHPGDKDM4E | |
| Hypoxanthine SCHEMBL30324467 | 0.63 | CYP1A2 (0.41) | PNPPDPK1HPGDKDM4EGAA | |
| Hypoxanthine SCHEMBL29467372 | 0.63 | CYP1A2 (0.41) | PNPPDPK1HPGDKDM4EGAA | |
| SCHEMBL14190552 | 0.63 | PDPK1 (0.76) | PNPPDPK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220856-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2002-07-10 | — | — | EP | disclosed |
| WO-2001027113-A2 | PYRAZOLO `4,3-d! PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | disclosed |