Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 8/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422389 | 0.88 | PDE5A (0.50) | PNPPDPK1KDM4EGAAHPGD | |
| SCHEMBL13691975 | 0.70 | PNP (0.62) | PNP | |
| SCHEMBL18521204 | 0.70 | PDPK1 (0.49) | PNPPDPK1CYP1A2TMIGD3CYP2C9 | |
| SCHEMBL1993929 | 0.67 | ADORA2A (0.40) | PNPPDPK1KDM4EGAAHPGD | |
| SCHEMBL6643757 | 0.66 | PNP (0.56) | PNP | |
| SCHEMBL3241296 | 0.66 | ALDH1A1 (0.35) | KDM4E | |
| SCHEMBL670236 | 0.65 | PDPK1 (0.46) | PNPPDPK1KDM4EHPGDPARP1 | |
| Hypoxanthine SCHEMBL29467372 | 0.64 | CYP1A2 (0.41) | PNPPDPK1KDM4EGAAHPGD | |
| Hypoxanthine SCHEMBL30324467 | 0.64 | CYP1A2 (0.41) | PNPPDPK1KDM4EGAAHPGD | |
| SCHEMBL14190552 | 0.64 | PDPK1 (0.76) | PNPPDPK1ACVR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220856-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2002-07-10 | — | — | EP | claimed |
| WO-2001027113-A2 | PYRAZOLO `4,3-d! PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | claimed |