Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 1.00 |
| ▸ | RXRB | P28702 | 9/20 | 1.00 |
| ▸ | RARB | P10826 | 10/20 | 0.64 |
| ▸ | RARG | P13631 | 10/20 | 0.64 |
| ▸ | RXRG | P48443 | 6/20 | 0.64 |
| ▸ | RARA | P10276 | 8/20 | 0.64 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.63 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760189 | 0.87 | RXRA (0.78) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL8458824 | 0.85 | RXRA (1.00) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL5888064 | 0.84 | RXRA (0.72) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL9519749 | 0.83 | RXRA (0.71) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL8681591 | 0.83 | RXRA (0.71) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL7759792 | 0.83 | RXRA (0.70) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL20646221 | 0.82 | RXRA (0.70) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL5083937 | 0.82 | RXRA (0.70) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL21794444 | 0.82 | RXRA (0.70) | RXRARXRBRARBRARGRXRG | |
| SCHEMBL7154631 | 0.82 | RXRA (0.70) | RXRARXRBRARBRARGRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5466861-A | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors | SRI INTERNATIONAL (US) | 1995-11-14 | — | — | US | disclosed |
| WO-1994012880-A2 | RXR HOMODIMER FORMATION AND BRIDGED BICYCLIC AROMATIC COMPOUNDS AND THEIR USE IN MODULATING GENE EXPRESSION | LA JOLLA CANCER RESEARCH FOUNDATION (US) | 1994-06-09 | — | — | WO | disclosed |