Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423371 | 0.91 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTCCR2ALOX5AP | |
| SCHEMBL7416354 | 0.89 | MAPT (0.43) | ALDH1A1KDM4EMAPTDPP4MEN1 | |
| SCHEMBL7419326 | 0.85 | SLC22A12 (0.45) | SLC22A12ALDH1A1CCR2PTPN11ALOX5AP | |
| SCHEMBL150104 | 0.84 | L3MBTL1 (0.47) | SLC22A12ALDH1A1CCR2PTPN11ALOX5AP | |
| SCHEMBL7463685 | 0.84 | ALOX5AP (0.44) | SLC22A12ALDH1A1CCR2PTPN11ALOX5AP | |
| SCHEMBL7418877 | 0.83 | SLC22A12 (0.43) | SLC22A12ALDH1A1KDM4EMAPTCCR2 | |
| SCHEMBL7421444 | 0.83 | KMT2A (0.54) | SLC22A12ALDH1A1MAPTCCR2PTPN11 | |
| SCHEMBL7427533 | 0.82 | ALOX5AP (0.46) | SLC22A12ALDH1A1CCR2PTPN11ALOX5AP | |
| SCHEMBL7425629 | 0.81 | KMT2A (0.44) | SLC22A12ALDH1A1MAPTCCR2PTPN11 | |
| SCHEMBL7707842 | 0.81 | ALOX5AP (0.45) | SLC22A12ALDH1A1CCR2PTPN11ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |