Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15300178 | 0.93 | CYP1A2 (0.44) | KDM4ELMNACYP1A2FAAHNPC1 | |
| SCHEMBL19897430 | 0.80 | CYP1A2 (0.42) | KDM4ELMNACYP1A2FAAHNPC1 | |
| SCHEMBL1233876 | 0.79 | CYP1A2 (0.41) | KDM4ELMNACYP1A2FAAHNPC1 | |
| SCHEMBL15784496 | 0.76 | MAPK1 (0.39) | KDM4ECYP1A2NPC1RAB9AKMT2A | |
| SCHEMBL1233517 | 0.75 | BAZ2B (0.54) | KDM4ELMNACYP1A2FAAHNPC1 | |
| SCHEMBL15300116 | 0.74 | KDM4E (0.46) | KDM4ECYP1A2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7426826 | 0.74 | KDM4E (0.46) | KDM4ECYP1A2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7698241 | 0.73 | LMNA (0.61) | KDM4ELMNACYP1A2FAAHNPC1 | |
| SCHEMBL537688 | 0.73 | CYP1A2 (0.47) | KDM4ELMNACYP1A2FAAHNPC1 | |
| SCHEMBL15519242 | 0.72 | CYP1A2 (0.46) | KDM4ELMNACYP1A2FAAHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003748-A2 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999012933-A2 | PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE | GLAXO GROUP LIMITED (GB) | 1999-03-18 | — | — | WO | disclosed |