Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703521 | 0.90 | LMNA (0.52) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL13279000 | 0.90 | LMNA (0.59) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL4759497 | 0.90 | LMNA (0.59) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1313891 | 0.90 | LMNA (0.52) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL24914925 | 0.89 | LMNA (0.54) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL24914933 | 0.89 | LMNA (0.51) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL27166556 | 0.88 | LMNA (0.51) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1312216 | 0.87 | LMNA (0.50) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL8003314 | 0.85 | LMNA (0.47) | LMNARAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL1894879 | 0.84 | LMNA (0.52) | LMNARAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230145793-A1 | SUBSTITUTED PYRIMIDINE OR PYRIDINE AMINE DERIVATIVE, COMPOSITION THEREOF, AND MEDICAL USE THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
| US-20160159805-A1 | Heterocyclic sulfonylamino(thio)carbonyl-derivatives with nematicidal properties | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-06-09 | — | — | US | disclosed |
| US-20160159805-A1 | Heterocyclic sulfonylamino(thio)carbonyl-derivatives with nematicidal properties | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-06-09 | — | — | US | disclosed |
| US-8778577-B2 | Colored composition, colored cured film, color filter, method for producing color filter, liquid crystal display device, solid-state imaging device, and novel dipyrromethene metal complex compound or tautomer thereof | FUJIFILM CORPORATION (JP) | 2014-07-15 | — | — | US | disclosed |
| US-20140038092-A1 | COLORED COMPOSITION, COLORED CURED FILM, COLOR FILTER, METHOD FOR PRODUCING COLOR FILTER, LIQUID CRYSTAL DISPLAY DEVICE, SOLID-STATE IMAGING DEVICE, AND NOVEL DIPYRROMETHENE METAL COMPLEX COMPOUND OR TAUTOMER THEREOF | FUJIFILM CORPORATION (JP) | 2014-02-06 | — | — | US | disclosed |
| US-7659289-B2 | Hydroxyethylene-based β-secretase inhibitors and use thereof | COMENTIS, INC. (US) | 2010-02-09 | — | — | US | disclosed |
| US-20080207527-A1 | Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof | COMENTIS, INC. (US) | 2008-08-28 | — | — | US | disclosed |
| US-20080125467-A1 | Amino-Containing Compounds Which Inhibit Memapsin 2 Beta-Secretase Activity and Methods of Use Thereof | COMENTIS, INC. | 2008-05-29 | — | — | US | disclosed |
| US-7335632-B2 | Beta-secretase inhibitors and methods of use thereof | COMENTIS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335632-B2 | Beta-secretase inhibitors and methods of use thereof | COMENTIS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| WO-2006034296-A2 | AMINO-CONTAINING COMPOUNDS WHICH INHIBIT MEMAPSIN 2 BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
| WO-2006034277-A1 | BICYCLIC COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125467-A1 | Amino-Containing Compounds Which Inhibit Memapsin 2 Beta-Secretase Activity and Methods of Use Thereof | BACE2, BACE1, PSEN2 | LMNA 862/4885RAB9A 2560/4885NPC1 1137/4885 |
| US-20160159805-A1 | Heterocyclic sulfonylamino(thio)carbonyl-derivatives with nematicidal properties | TST, TUBB, TUBA3C | LMNA 3434/4885RAB9A 1352/4885NPC1 1872/4885 |
| US-20230145793-A1 | SUBSTITUTED PYRIMIDINE OR PYRIDINE AMINE DERIVATIVE, COMPOSITION THEREOF, AND MEDICAL USE THEREOF | ADORA2A, ADORA2B, ADORA3 | LMNA 3817/4885RAB9A 2881/4885NPC1 2908/4885 |
| US-20080207527-A1 | Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof | BACE1, BACE2, PSEN1 | LMNA 518/4885RAB9A 2377/4885NPC1 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.