Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 2/20 | 0.30 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27934672 | 0.75 | — | — | |
| SCHEMBL8486133 | 0.72 | — | — | |
| SCHEMBL8664070 | 0.69 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL2953547 | 0.69 | TSHR (0.39) | ANPEPALDH1A1TSHRMAPK1DNPEP | |
| SCHEMBL23343276 | 0.66 | — | — | |
| SCHEMBL10580204 | 0.66 | — | — | |
| SCHEMBL20845811 | 0.66 | — | — | |
| SCHEMBL20763921 | 0.66 | — | — | |
| SCHEMBL4407497 | 0.66 | — | — | |
| SCHEMBL5740524 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191277-B1 | AND INTERMEDIATES THEREOF ATTACHED TO A SOLID PHASE SUPPORT, USEFUL FOR TREATMENT OF MALARIA AND ALZHEIMER'S DISEASE; INHIBITORY ACTIVITY AGAINST PLASMEPSIN AND CATHEPSIN D | PHARMACOPEIA, INC. | 2001-02-20 | — | — | US | disclosed |
| US-5986102-A | ENZYME INHIBITORS OF ASPARTYL PROTEASES | PHARMACOPEIA, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1999055687-A2 | HYDROXYPROPYLAMIDE PEPTIDOMIMETICS AS INHIBITORS OF ASPARTYL PROTEASES | PHARMACOPEIA, INC. (US) | 1999-11-04 | — | — | WO | disclosed |