Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 12/20 | 0.57 |
| ▸ | MMP1 | P03956 | 11/20 | 0.57 |
| ▸ | MMP2 | P08253 | 10/20 | 0.57 |
| ▸ | MMP13 | P45452 | 10/20 | 0.57 |
| ▸ | MMP3 | P08254 | 9/20 | 0.57 |
| ▸ | MMP7 | P09237 | 9/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.55 |
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1656896 | 0.94 | MMP2 (0.61) | MMP9MMP1MMP2MMP13MMP3 | |
| SCHEMBL3615326 | 0.94 | MMP2 (0.61) | MMP9MMP1MMP2MMP13MMP3 | |
| SCHEMBL8283236 | 0.94 | MMP2 (0.61) | MMP9MMP1MMP2MMP13MMP3 | |
| SCHEMBL7867746 | 0.90 | MMP2 (0.68) | MMP9MMP1MMP2MMP13MMP3 | |
| SCHEMBL7763738 | 0.90 | MMP2 (0.68) | MMP9MMP1MMP2MMP13MMP3 | |
| SCHEMBL6394008 | 0.85 | MMP9 (0.64) | MMP9MMP1MMP2MMP13MMP3 | |
| SCHEMBL5093836 | 0.85 | MMP9 (0.64) | MMP9MMP1MMP2MMP13MMP3 | |
| SCHEMBL7087648 | 0.85 | MMP9 (0.64) | MMP9MMP1MMP2MMP13MMP3 | |
| SCHEMBL7867268 | 0.82 | MMP2 (0.71) | MMP9MMP1MMP2MMP13MMP3 | |
| SCHEMBL14176097 | 0.81 | MMP9 (0.47) | MMP9MMP1MMP2MMP13MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | disclosed |