Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001044 | 0.78 | MAPT (0.59) | MAPTKMT2ANPC1GAATDP1 | |
| SCHEMBL6001045 | 0.78 | MAPT (0.59) | MAPTKMT2ANPC1GAATDP1 | |
| SCHEMBL1444136 | 0.72 | MAPT (0.54) | MAPTNPC1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL1444503 | 0.72 | MAPT (0.54) | MAPTNPC1SMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL7421627 | 0.72 | KDR (0.48) | MAPTKMT2ANPC1TDP1SMN1; SMN2 | |
| SCHEMBL7534633 | 0.70 | GSK3B (0.47) | MAPTKMT2AGSK3BPOLBSMN1; SMN2 | |
| SCHEMBL7416167 | 0.70 | ALDH1A1 (0.61) | MAPTKMT2ANPC1TDP1GSK3B | |
| SCHEMBL7421881 | 0.70 | EGFR (0.51) | MAPTKMT2ANPC1TDP1POLB | |
| SCHEMBL7422702 | 0.69 | GSK3B (0.49) | MAPTKMT2ANPC1GAATDP1 | |
| SCHEMBL7421021 | 0.69 | GSK3B (0.46) | MAPTKMT2ANPC1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769947-A4 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 1998-09-30 | — | — | EP | disclosed |
| EP-0769947-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996040116-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |