Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466283 | 0.92 | KIF11 (0.58) | KDM4EHSD17B10MAPTALOX15SMN1; SMN2 | |
| SCHEMBL6070647 | 0.90 | KDM4E (0.72) | KDM4EHSD17B10MAPTALOX15SMN1; SMN2 | |
| SCHEMBL25234433 | 0.84 | PARP1 (0.61) | KDM4EHSD17B10SMN1; SMN2KIF11PARP1 | |
| SCHEMBL30414035 | 0.84 | PARP1 (0.61) | KDM4EHSD17B10SMN1; SMN2KIF11PARP1 | |
| SCHEMBL6449055 | 0.84 | HSD17B10 (0.59) | KDM4EHSD17B10MAPTALOX15SMN1; SMN2 | |
| SCHEMBL30666090 | 0.82 | PARP1 (0.61) | KDM4EHSD17B10SMN1; SMN2KIF11PARP1 | |
| SCHEMBL2485234 | 0.80 | MAPT (0.61) | KDM4EHSD17B10MAPTSMN1; SMN2KIF11 | |
| SCHEMBL6688391 | 0.79 | MAPT (0.60) | KDM4EHSD17B10MAPTSMN1; SMN2KIF11 | |
| SCHEMBL4109708 | 0.79 | HSD17B10 (0.59) | KDM4EHSD17B10MAPTSMN1; SMN2MEN1 | |
| SCHEMBL30493571 | 0.76 | PARP1 (0.54) | KDM4EHSD17B10SMN1; SMN2KIF11PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |