Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.58 |
| ▸ | PARP1 | P09874 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423733 | 0.92 | KDM4E (0.59) | KIF11PARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL6070647 | 0.82 | KDM4E (0.72) | KIF11PARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL31360033 | 0.80 | KDM4E (0.51) | KIF11PARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL6070994 | 0.79 | KIF11 (0.50) | KIF11PARP1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL6071240 | 0.79 | MAPK10 (0.66) | KIF11KDM4EHSD17B10MAPTALOX15 | |
| SCHEMBL25234433 | 0.78 | PARP1 (0.61) | KIF11PARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL30414035 | 0.78 | PARP1 (0.61) | KIF11PARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL30666090 | 0.78 | PARP1 (0.61) | KIF11PARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL29708168 | 0.77 | KIF11 (0.84) | KIF11PARP1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL4725998 | 0.77 | KIF11 (0.84) | KIF11PARP1KDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |