Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.71 |
| ▸ | F10 | P00742 | 11/20 | 0.70 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6432819 | 0.86 | F10 (0.84) | CCR2F10PLA2G10F2 | |
| SCHEMBL27513366 | 0.86 | CCR2 (0.72) | CCR2F10PLA2G10GPR35 | |
| SCHEMBL25017563 | 0.84 | F10 (0.60) | CCR2F10PLA2G10F2 | |
| SCHEMBL5378162 | 0.84 | CCR2 (1.00) | CCR2F10PLA2G10GPR35 | |
| Hydrochloric Acid SCHEMBL6434172 | 0.83 | F10 (0.85) | F10F2 | |
| SCHEMBL6436953 | 0.82 | F10 (1.00) | CCR2F10F2 | |
| Hydrochloric Acid SCHEMBL6436952 | 0.82 | F10 (0.98) | CCR2F10F2 | |
| SCHEMBL3961949 | 0.81 | CCR2 (1.00) | CCR2GPR35 | |
| SCHEMBL29845455 | 0.80 | CCR2 (0.81) | CCR2F10PLA2G10GPR35 | |
| SCHEMBL7008246 | 0.80 | CCR2 (0.81) | CCR2PLA2G10GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |