Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19520949 | 1.00 | TRPM8 (0.58) | TRPM8MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL7424214 | 1.00 | TRPM8 (0.58) | TRPM8MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL30220325 | 1.00 | TRPM8 (0.58) | TRPM8MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL19520951 | 1.00 | TRPM8 (0.58) | TRPM8MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL16851474 | 1.00 | TRPM8 (0.58) | TRPM8MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL1109206 | 0.91 | ALDH1A1 (0.52) | TRPM8MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL1095999 | 0.91 | ALDH1A1 (0.52) | TRPM8MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL24326690 | 0.89 | TRPM8 (0.59) | TRPM8MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL1889631 | 0.89 | TRPM8 (0.59) | TRPM8MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL1889629 | 0.89 | TRPM8 (0.59) | TRPM8MAPTL3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900211-A1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1999-03-10 | — | — | EP | claimed |
| WO-1997040031-A1 | THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-10-30 | — | — | WO | claimed |