Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 14/20 | 0.48 |
| ▸ | MMP1 | P03956 | 11/20 | 0.48 |
| ▸ | MMP9 | P14780 | 10/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 4/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.43 |
| ▸ | MMP8 | P22894 | 4/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423215 | 0.88 | MMP3 (0.61) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL7426986 | 0.87 | MMP3 (0.42) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL7427472 | 0.84 | MMP1 (0.48) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL6076031 | 0.84 | MMP3 (0.47) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL7417107 | 0.84 | MMP1 (0.56) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL8155835 | 0.83 | MMP1 (0.47) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL6076126 | 0.81 | MMP3 (0.47) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL6075691 | 0.80 | MMP3 (0.49) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL6075406 | 0.80 | MMP3 (0.46) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL7389960 | 0.80 | MMP1 (0.57) | MMP3MMP1MMP9MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040099-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Amgen Inc., (US) | 2000-10-04 | — | — | EP | disclosed |
| US-6107291-A | ANTIINFLAMMATORY AGENT | AMGEN INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1999032451-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AMGEN INC. (US) | 1999-07-01 | — | — | WO | disclosed |