Acetone

Acetone

SCHEMBL742461

CC(C)=O.CO.ClCCl

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetone SCHEMBL1320683 0.96 LMNA (0.50)
Acetone SCHEMBL2391921 0.96 LMNA (0.50)
Acetone SCHEMBL292856 0.95 LMNA (0.60)
Acetone SCHEMBL6859028 0.95 LMNA (0.60)
Acetone SCHEMBL1831044 0.95 LMNA (0.60)
Acetone SCHEMBL9324675 0.95 LMNA (0.60)
Acetone SCHEMBL9217023 0.95 LMNA (0.60)
Acetone SCHEMBL6859386 0.95 LMNA (0.60)
Acetone SCHEMBL1244296 0.95 LMNA (0.60)
Acetone SCHEMBL6859109 0.95 LMNA (0.60)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 345 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113125627-B Detection method for effective components of traditional Chinese medicine composition for treating nephropathy 云南雷允上理想药业有限公司 2022-10-18 CN claimed
CN-113125627-A Detection method for effective components of traditional Chinese medicine composition for treating nephropathy 云南雷允上理想药业有限公司 2021-07-16 CN claimed
CN-108484711-B A method of preparing gypenoside LI 海门市彼维知识产权服务有限公司 2019-04-05 CN claimed
CN-108276466-B A method of preparing gypenoside LVI 娄志春 2019-03-08 CN claimed
CN-108484712-B A method of preparing damulin A 娄志春 2019-03-08 CN claimed
CN-108484713-B A method of preparing gypenoside L 娄志春 2019-03-05 CN claimed
CN-108410940-B A kind of method that microbe transformation method prepares damulin B 娄志春 2019-03-05 CN claimed
CN-108440631-B A method of preparing gypenoside XLVI 绍兴市逸晨医疗科技有限公司 2018-12-21 CN claimed
CN-108179169-B A kind of method that microbe transformation method prepares damulin A 江苏天芳健康科技有限公司 2018-11-23 CN claimed
CN-108178778-B A method of preparing damulin B 邳州高新区生物医药研究院有限公司 2018-11-20 CN claimed
CN-108484713-A A method of preparing gypenoside L 娄志春 2018-09-04 CN claimed
CN-108484711-A A method of preparing gypenoside LI 娄志春 2018-09-04 CN claimed
CN-108484712-A A method of preparing damulin A 娄志春 2018-09-04 CN claimed
CN-108459129-A A kind of method of quality control of Tetrandra and Poria Decoction composition 华润三九医药股份有限公司 2018-08-28 CN claimed
CN-108410940-A A kind of method that microbe transformation method prepares damulin B 娄志春 2018-08-17 CN claimed
CN-108179169-A A kind of method that microbe transformation method prepares damulin A 娄志春 2018-06-19 CN claimed
CN-108178778-A A kind of method for preparing damulin B 娄志春 2018-06-19 CN claimed
CN-105980390-B A kind of crystal form of disulfate of jak kinase inhibitor and preparation method thereof 江苏恒瑞医药股份有限公司 2017-07-07 CN claimed
CN-106589043-A Application of aryl substitute acryl triterpenoids to preparation of anticomplement drugs 复旦大学 2017-04-26 CN claimed
CN-117347514-A Thin-layer chromatography identification method for canna plant 广西天缘绿生物科技有限公司 2024-01-05 CN disclosed
CN-112972438-B Lignan compound from radix paeoniae rubra, and preparation method and application thereof 中国医学科学院药物研究所 2023-05-05 CN disclosed
CN-113125627-B Detection method for effective components of traditional Chinese medicine composition for treating nephropathy 云南雷允上理想药业有限公司 2022-10-18 CN disclosed
CN-113125627-A Detection method for effective components of traditional Chinese medicine composition for treating nephropathy 云南雷允上理想药业有限公司 2021-07-16 CN disclosed
CN-112972438-A Lignan compounds derived from radix paeoniae rubra as well as preparation method and application thereof 中国医学科学院药物研究所 2021-06-18 CN disclosed
CN-107513089-B Novel cytidine derivative dimer and application thereof 常州方圆制药有限公司 2021-04-02 CN disclosed
CN-107652339-B Novel cytidine derivative and application thereof 常州方圆制药有限公司 2021-04-02 CN disclosed
CN-107501369-B Preparation method and application of cytidine derivative 常州方圆制药有限公司 2020-05-15 CN disclosed
US-10508092-B2 Synthesis of novel analogs of diptoindonesin G, compounds formed thereby, and pharmaceutical compositions containing them WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2019-12-17 US disclosed
CN-106146583-B Novel cytidine derivative and use thereof 常州方圆制药有限公司 2019-11-08 CN disclosed
CN-106866652-B Jamaicin 12- bit derivant with insulin-sensitizing activity and preparation method thereof 四川大学 2019-04-23 CN disclosed
CN-108484711-B A method of preparing gypenoside LI 海门市彼维知识产权服务有限公司 2019-04-05 CN disclosed
CN-108484712-B A method of preparing damulin A 娄志春 2019-03-08 CN disclosed
CN-108276466-B A method of preparing gypenoside LVI 娄志春 2019-03-08 CN disclosed
CN-108410940-B A kind of method that microbe transformation method prepares damulin B 娄志春 2019-03-05 CN disclosed
CN-108484713-B A method of preparing gypenoside L 娄志春 2019-03-05 CN disclosed
CN-106146584-B Novel cytidine derivative dimer and use thereof 常州方圆制药有限公司 2019-03-01 CN disclosed
CN-106589043-B Aryl substituted acryl triterpene compound is preparing the purposes in anticomplement medicament 复旦大学 2019-02-26 CN disclosed
CN-108440631-B A method of preparing gypenoside XLVI 绍兴市逸晨医疗科技有限公司 2018-12-21 CN disclosed
CN-108178778-B A method of preparing damulin B 邳州高新区生物医药研究院有限公司 2018-11-20 CN disclosed
CN-108484713-A A method of preparing gypenoside L 娄志春 2018-09-04 CN disclosed
CN-108484712-A A method of preparing damulin A 娄志春 2018-09-04 CN disclosed
CN-108484711-A A method of preparing gypenoside LI 娄志春 2018-09-04 CN disclosed
CN-108459129-A A kind of method of quality control of Tetrandra and Poria Decoction composition 华润三九医药股份有限公司 2018-08-28 CN disclosed
CN-108440631-A A method of preparing gypenoside XLVI 娄志春 2018-08-24 CN disclosed
CN-108276466-A A method of preparing gypenoside LVI 娄志春 2018-07-13 CN disclosed
CN-108178778-A A kind of method for preparing damulin B 娄志春 2018-06-19 CN disclosed
EP-2495234-B1 AROMATIC SULFONIUM SALT COMPOUND ADEKA CORP (JP) 2018-06-06 EP disclosed
US-20180065945-A1 SYNTHESIS OF NOVEL ANALOGS OF DIPTOINDONESIN G, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY 2018-03-08 US disclosed
CN-105980390-B A kind of crystal form of disulfate of jak kinase inhibitor and preparation method thereof 江苏恒瑞医药股份有限公司 2017-07-07 CN disclosed
CN-106589043-A Application of aryl substitute acryl triterpenoids to preparation of anticomplement drugs 复旦大学 2017-04-26 CN disclosed
EP-2896612-A1 Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors Wyeth Holdings LLC (US) 2015-07-22 EP disclosed
CN-104706718-A Three-ingredient Chinese gentian flower tablets and preparation method thereof SICHUAN YUTUO TIBETAN MEDICINE INDUSTRY CO LTD 2015-06-17 CN disclosed
CN-102590434-B Detection method of preparation comprising eight Chinese herbal medicines for calming TIBETAN CHEEZHENG TIBETAN MEDICINE CO LTD 2014-08-13 CN disclosed
CN-102520113-B Detection method for fifteen Rupeng preparation TIBETAN CHEEZHENG TIBETAN MEDICINE CO LTD 2014-05-07 CN disclosed
EP-2253620-B1 SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS WYETH HOLDINGS LLC (US) 2014-03-12 EP disclosed
CN-103570747-A Preparation technology for cefbuperazone sodium ANHUI YOUCARE KAIYUE PHARMACEUTICAL CO LTD 2014-02-12 CN disclosed
US-20140034623-A1 SWITCHABLE SPECIAL EFFECT SUBSTANCES BASF SE (DE) 2014-02-06 US disclosed
US-8586745-B2 Switchable special effect substances BASF SE (DE) 2013-11-19 US disclosed
EP-2431370-B1 Monoacylated 1,2-diaminocycloalkanes DAIICHI SANKYO CO LTD (JP) 2013-06-19 EP disclosed
US-8304406-B2 Compounds for treating pulmonary hypertension BAYER INTELLECTUAL PROPERTY GMBH (DE) 2012-11-06 US disclosed
EP-1577301-B1 Antithrombotic diaminocyclohexane derivatives DAIICHI SANKYO CO LTD (JP) 2012-09-12 EP disclosed
EP-2495234-A1 AROMATIC SULFONIUM SALT COMPOUND Adeka Corporation (JP) 2012-09-05 EP disclosed
US-8236795-B2 IL-12 modulatory compounds SYNTA PHARMACEUTICALS CORP. (US) 2012-08-07 US disclosed
EP-1270557-B1 ETHYLENEDIAMINE DERIVATIVES DAIICHI SANKYO CO LTD (JP) 2012-07-25 EP disclosed
CN-102590434-A Detection method of preparation comprising eight Chinese herbal medicines for calming TIBETAN CHEEZHENG TIBETAN MEDICINE CO LTD 2012-07-18 CN disclosed
CN-102520113-A Detection method for fifteen Rupeng preparation TIBETAN CHEEZHENG TIBETAN MEDICINE CO LTD 2012-06-27 CN disclosed
US-20120130117-A1 AROMATIC SULFONIUM SALT COMPOUND ADEKA CORPORATION (JP) 2012-05-24 US disclosed
CN-101363819-B Quality control method for yuye qinghuo capsule GUANGXI BOKE PHARMACEUTICAL CO LTD 2012-04-18 CN disclosed
EP-2431370-A1 Monoacylated 1,2-diaminocycloalkanes DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2012-03-21 EP disclosed
US-20110312990-A1 Diamine Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2011-12-22 US disclosed
US-20110263597-A1 SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY BAYER HEALTHCARE LLC (US) 2011-10-27 US disclosed
EP-2343290-A1 Diamine derivatives as factor X inhibitors Daiichi Sankyo Company, Limited (JP) 2011-07-13 EP disclosed
US-7977333-B2 Hyperpermeability; diabetic retinopathy, ischemic retinal-vein occlusion, prematurity, age-related macular degeneration BAYER HEALTHCARE LLC (US) 2011-07-12 US disclosed
US-RE42376-E1 Substituted 3-cyanoquinolines WYETH HOLDINGS CORPORATION (US) 2011-05-17 US disclosed
US-7935824-B2 Ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2011-05-03 US disclosed
US-7919487-B2 Heteroaryl compounds SYNTA PHARMACEUTICALS CORPORATION (US) 2011-04-05 US disclosed
US-20110077266-A1 Diamine Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2011-03-31 US disclosed
US-20110060113-A1 SWITCHABLE SPECIAL EFFECT SUBSTANCES BASF SE (DE) 2011-03-10 US disclosed
EP-2253620-A1 Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors Wyeth Holdings Corporation (US) 2010-11-24 EP disclosed
US-20100256132-A1 IL-12 MODULATORY COMPOUNDS SYNTA PHARMACEUTICALS CORPORATION (US) 2010-10-07 US disclosed
US-20100120722-A1 HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS SYNTA PHARMACEUTICALS CORP. (US) 2010-05-13 US disclosed
US-20100113452-A1 COMPOUNDS FOR TREATING PULMONARY HYPERTENSION BAYER HEALTHCARE AG (DE) 2010-05-06 US disclosed
US-20100099660-A1 METHOD FOR TREATING THROMBOSIS OR EMBOLISM AND RELATED DISEASES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2010-04-22 US disclosed
US-20100093785-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2010-04-15 US disclosed
US-7696202-B2 IL-12 modulatory compounds SYNTA PHARMACEUTICALS CORP. (US) 2010-04-13 US disclosed
US-20090281074-A1 DRUG COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING THROMBOSIS OR EMBOLISM DAIICHI PHARMACEUTICAL CO., LTD (JP) 2009-11-12 US disclosed
US-20090270446-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2009-10-29 US disclosed
EP-1754475-B1 Use of C-terminal modified oxamyl dipeptides as inhibitors of the ice/ced-3 family of cysteine proteases IDUN PHARMACEUTICALS INC (US) 2009-09-16 EP disclosed
US-20090227789-A1 ETHYLENEDIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2009-09-10 US disclosed
US-7576135-B2 Diamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2009-08-18 US disclosed
EP-1228063-B1 SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY BAYER CORP (US) 2009-02-11 EP disclosed
CN-101363819-A Quality control method for yuye qinghuo capsule GUANGXI BOKE PHARMACEUTICAL CO (CN) 2009-02-11 CN disclosed
EP-2010173-A1 COMPOUNDS FOR TREATING PULMONARY HYPERTENSION Bayer HealthCare AG (DE) 2009-01-07 EP disclosed
EP-1212339-B1 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS INC (US) 2008-12-31 EP disclosed
CN-100422173-C Substituted pyridines and pyridazines with angiogenesis inhibiting activity BAYER PHARMACEUTICALS CORP (US) 2008-10-01 CN disclosed
CN-100422172-C Substituted pyridines and pyridazines with angiogenesis inhibiting activity BAYER PHARMACEUTICALS CORP (US) 2008-10-01 CN disclosed
US-7410990-B2 Heterocyclic compounds SYNTA PHARMACEUTICALS CORP. (US) 2008-08-12 US disclosed
EP-1950201-A1 Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors Wyeth Holdings Corporation (US) 2008-07-30 EP disclosed
US-7365205-B2 Cyclic diamine derivatives useful as agents for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism; inhibit activated blood coagulation factor X DAIICHI SANKYO COMPANY, LIMITED (JP) 2008-04-29 US disclosed
CN-100374435-C Substituted pyridazines having angiogenesis inhibiting activity BAYER CORP (US) 2008-03-12 CN disclosed
US-7342014-B2 Diamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2008-03-11 US disclosed
US-20080058297-A1 Heterocyclic Compounds For Preventing And Treating Disorders Associated With Excessive Bone Loss SYNTA PHARMACEUTICALS CORP. (US) 2008-03-06 US disclosed
US-20080015215-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2008-01-17 US disclosed
WO-2007118602-A1 COMPOUNDS FOR TREATING PULMONARY HYPERTENSION BAYER HEALTHCARE AG (DE) 2007-10-25 WO disclosed
EP-1819341-A2 IL-12 MODULATORY COMPOUNDS Synta Pharmaceuticals Corporation (US) 2007-08-22 EP disclosed
US-7192968-B2 Ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2007-03-20 US disclosed
US-7183260-B2 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases IDUN PHARMACEUTICALS, INC. (US) 2007-02-27 US disclosed
EP-1754475-A1 Use of C-terminal modified oxamyl dipeptides as inhibitors of the ice/ced-3 family of cysteine proteases Idun Pharmaceuticals, Inc. (US) 2007-02-21 EP disclosed
EP-1575900-A4 N-METHYL AMINO ACIDS UBIQUITOUS TECHNOLOGIES PTY LT (AU) 2007-02-21 EP disclosed
US-20070027151-A1 Heterocyclic compounds SYNTA PHARMACEUTICALS CORP. (US) 2007-02-01 US disclosed
US-7157430-B2 (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases IDUN PHARMACEUTICALS, INC. (US) 2007-01-02 US disclosed
US-20060252837-A1 Cyclic diamine derivatives useful as agents for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism; inhibit activated blood coagulation factor X DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-11-09 US disclosed
CN-1283656-C C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases IDUN PHARMACEUTICALS INC (US) 2006-11-08 CN disclosed
US-7122665-B2 Heterocyclic compounds SYNTA PHARMACEUTICALS CORP. (US) 2006-10-17 US disclosed
US-20060223996-A1 IL-12 modulatory compounds SYNTA PHARMACEUTICALS CORP. (US) 2006-10-05 US disclosed
US-7071195-B2 Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2006-07-04 US disclosed
US-20060122156-A1 Heteroaryl compounds SYNTA PHARMACEUTICALS CORP. (US) 2006-06-08 US disclosed
US-7053056-B2 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases IDUN PHARMACEUTICALS, INC. (US) 2006-05-30 US disclosed
US-20060111553-A1 Novel thrombin inhibitors, the preparation and use thereof ABBOTT GMBH & CO. KG (DE) 2006-05-25 US disclosed
WO-2006053227-A2 IL-12 MODULATORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2006-05-18 WO disclosed
WO-2006053109-A1 HETEROARYL COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2006-05-18 WO disclosed
CN-1769282-A Substituted pyridines and pyridazines with angiogenesis inhibiting activity BAYER PHARMACEUTICALS CORP (US) 2006-05-10 CN disclosed
CN-1769283-A Substituted pyridines and pyridazines with angiogenesis inhibiting activity BAYER PHARMACEUTICALS CORP (US) 2006-05-10 CN disclosed
EP-1647279-A2 Inhibition of apoptosis using interleukin-1beta-converting enzyme (ICE)/CED-3 family inhibitors Idun Pharmaceuticals, Inc. (US) 2006-04-19 EP disclosed
US-20060052388-A1 Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders DAX SCOTT L 2006-03-09 US disclosed
EP-1626725-A2 HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS Synta Pharmaceuticals Corporation (US) 2006-02-22 EP disclosed
EP-0929311-B8 INHIBITION OF APOPTOSIS USING INTERLEUKIN-1 beta-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS IDUN PHARMACEUTICALS INC (US) 2006-02-01 EP disclosed
US-20060004009-A1 Ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-01-05 US disclosed
EP-0929311-B1 INHIBITION OF APOPTOSIS USING INTERLEUKIN-1 beta-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS IDUN PHARMACEUTICALS INC (US) 2005-11-23 EP disclosed
US-20050245565-A1 Diamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-11-03 US disclosed
US-20050245432-A1 N-methyl amino acids UBIQUITOUS TECHNOLOGIES PTY. LTD. (AU) 2005-11-03 US disclosed
EP-1577301-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-09-21 EP disclosed
EP-1575900-A1 N-METHYL AMINO ACIDS UBIQUITOUS TECHNOLOGIES PTY LTD (AU) 2005-09-21 EP disclosed
CN-1213044-C Amine and amide derivatives as ligands of the neuropeptide YY5 receptor for the treatment of obesity and other diseases ORTHO MCNEIL PHARM INC (US) 2005-08-03 CN disclosed
US-6903101-B1 Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity BAYER PHARMACEUTICALS CORPORATION (US) 2005-06-07 US disclosed
US-20050119486-A1 Diamine derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2005-06-02 US disclosed
US-6900319-B2 Thrombin inhibitors ABBOTT GMBH & CO. KG (DE) 2005-05-31 US disclosed
US-6897230-B2 Bicyclo[3/1/0] hexane containing oxazolidinone antibiotics and derivatives thereof KYORIN PHARMACEUTICAL CO., LTD. (JP) 2005-05-24 US disclosed
US-20050020504-A1 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases IDUN PHARMACEUTICALS, INC. (US) 2005-01-27 US disclosed
US-20050020645-A1 Diamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-01-27 US disclosed
WO-2005000404-A2 HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS SYNTA PHARMACEUTICALS, CORP. (US) 2005-01-06 WO disclosed
EP-1493742-A1 Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders Ortho-Mcneil Pharmaceutical, Inc. (US) 2005-01-05 EP disclosed
EP-0869958-B1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH AS (DK) 2004-12-29 EP disclosed
EP-1066037-B1 USE OF INDOLE-2,3-DIONE-3-OXIME DERIVATIVES AS AMPA ANTAGONISTS NEUROSEARCH AS (DK) 2004-12-29 EP disclosed
US-20040259804-A1 (Substituted)Acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases IDUN PHARMACEUTICALS, INC. 2004-12-23 US disclosed
EP-0972775-B1 PYRROLOINDOLE DERIVATIVES AND INTERMEDIATES IN PRODUCING THE SAME KYORIN SEIYAKU KK (JP) 2004-12-08 EP disclosed
EP-1480999-A2 (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES Idun Pharmaceuticals (US) 2004-12-01 EP disclosed
EP-1311300-A4 RADIOLIGAND AND BINDING ASSAY MERCK & CO INC (US) 2004-11-03 EP disclosed
CN-1535958-A Alpha-substituted pyrimidine. thioalkyl and alkyl ether compound �������Ŷ���Լ��������˾ 2004-10-13 CN disclosed
US-20040198725-A1 A bi-heterocyclic compound e.g 3-methoxyphenyl)-{6-Morpholin-4-yl-2-[2-(pyridin-2-yloxy)-ethoxy]-9H-purin-8-yl}-amine or other derivatives useful for treating an interleukin-12 overproduction-related disorder such as rheumatoid arthritis, sepsis, Crohn's disease, multiple sclerosis, psoriasis or diabetes SYNTA PHARMACEUTICALS CORP. 2004-10-07 US disclosed
EP-0824524-B1 ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE UPJOHN CO (US) 2004-09-08 EP disclosed
CN-1525978-A C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 伊邓药品公司 2004-09-01 CN disclosed
EP-1449835-A2 Alpha-substituted pyrimidine-thioalkyl and alkylether compounds PHARMACIA &amp; UPJOHN COMPANY (US) 2004-08-25 EP disclosed
EP-1443935-A2 TREATMENT OF INFECTIOUS DISEASE USING INTERLEUKIN-1 BETA CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS Idun Pharmaceuticals, Inc. (US) 2004-08-11 EP disclosed
CN-1159289-C C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cystenine proteases ������˹ҩƷ��˾ 2004-07-28 CN disclosed
US-6759384-B1 LOW MOLECULAR WEIGHT ANTICOAGULANTS WITHOUT SIDE EFFECTS; DERIVATIVES OF AT LEAST PROLINE, LEUCINE AND ARGININE SEQUENCE AVENTIS PHARMACEUTICALS INC. 2004-07-06 US disclosed
US-20040122063-A1 Ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-24 US disclosed
EP-1023316-A4 METHODS AND COMPOSITIONS FOR LIPIDIZATION OF HYDROPHILIC MOLECULES UNIV SOUTHERN CALIFORNIA (US) 2004-06-09 EP disclosed
US-6747023-B1 INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-08 US disclosed
CN-1152022-C Alpha-substituted pyrimidine-thioalkyl and alkylether compounds �������Ŷ���Լ��������˾ 2004-06-02 CN disclosed
US-20040092740-A1 Substituted pyridines and pyridazines with angiogenesis inhibiting activity BAYER PHARMACEUTICALS CORPORATION 2004-05-13 US disclosed
EP-1415992-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-05-06 EP disclosed
US-20040082611-A1 Anticoagulants; brain disorders; respiratory system disorders; side effect reduction DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-29 US disclosed
EP-1208096-B1 SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY BAYER AG (US) 2004-04-28 EP disclosed
EP-1405852-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-07 EP disclosed
US-20040058850-A1 Using caspase inhibitor; antiinflammatory agents IDUN PHARMACEUTICALS, INC. 2004-03-25 US disclosed
EP-0758341-B1 FACTOR Xa INHIBITORS AVENTIS PHARMA INC (US) 2004-03-24 EP disclosed
EP-1118616-B1 Process for the production of 5'-nor-anhydrovinblastine ditartrate from plants of genus catharanthus ERIOCHEM SA (AR) 2004-03-24 EP disclosed
US-RE38460-E1 Huperzine A derivatives, their preparation and their use SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES (CN) 2004-03-09 US disclosed
WO-2004014882-A2 PROTEASOME INHIBITORS : PEPTIDE DERIVATIVES HAVING C-TERMINAL HETEROARYL GROUPS AXYS PHARMACEUTICALS (US) 2004-02-19 WO disclosed
US-6693096-B2 SUPPRESSING PROTEASE ACTIVITY IDUN PHARMACEUTICALS, INC. 2004-02-17 US disclosed
US-6693111-B1 1H-PYRROLO(3,2-H)ISOQUINOLINE DERIVATIVES; EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS NEUROSEARCH A/S (DK) 2004-02-17 US disclosed
US-6689883-B1 Substituted pyridines and pyridazines with angiogenesis inhibiting activity BAYER PHARMACEUTICALS CORPORATION 2004-02-10 US disclosed
EP-1384725-A2 Factor Xa inhibitors Aventis Pharmaceuticals, Inc. (US) 2004-01-28 EP disclosed
WO-2004007427-A1 N-METHYL AMINO ACIDS UBIQUITOUS TECHNOLOGIES PTY LTD (AU) 2004-01-22 WO disclosed
US-20030232788-A1 (Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases IDUN PHARMACEUTICALS, INC. 2003-12-18 US disclosed
EP-1117659-B1 SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS WYETH CORP (US) 2003-12-03 EP disclosed
EP-1351975-A2 C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES Idun Pharmaceuticals, Inc. (US) 2003-10-15 EP disclosed
US-20030186842-A1 Contacting a cell population with an inhibiting effective amount of a reagent that suppresses the protease activity of at least one member of the interleukin-1beta- converting enzyme (ICE)/CED-3 family IDUN PHARMACEUTICALS, INC. (US) 2003-10-02 US disclosed
WO-2003072528-A2 (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES IDUN PHARMACEUTICALS, INC. (US) 2003-09-04 WO disclosed
US-6610683-B2 Programmed cell death; expansion of hematopoietic cells, for prolonging viability of an organ for transplantation, and maintaining viability of cell lines used in bioproduction IDUN PHARMACEUTICALS, INC. 2003-08-26 US disclosed
EP-0680962-B1 Heterocyclic compounds ASTRAZENECA AB (SE) 2003-08-20 EP disclosed
US-RE38200-E1 Capable of antagonizing effect of excitatory amino acids, such as glutamate NEUROSEARCH A/S (DK) 2003-07-22 US disclosed
US-20030125367-A1 Bicyclo[3,1,0]hexane containing oxazolidinone antibioytics and derivatives thereof KYORIN PHARMACEUTICAL CO., LTD. 2003-07-03 US disclosed
US-6579569-B2 Uses multi-slot coating apparatus to apply multiple liquid layers to moving substrate; high speed, for photographic film and paper products EASTMAN KODAK COMPANY 2003-06-17 US disclosed
CN-1420879-A Substituted pyridines and pyridazines having angiogenesis inhibiting activity BAYER AG (US) 2003-05-28 CN disclosed
EP-1311300-A1 RADIOLIGAND AND BINDING ASSAY Merck & Co., Inc. (US) 2003-05-21 EP disclosed
WO-2003032918-A2 TREATMENT OF INFECTIOUS DISEASE USING INTERLEUKIN-1 BETA CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS IDUN PHARMACEUTICALS, INC. (US) 2003-04-24 WO disclosed
US-6544951-B2 Antiinflammatory agents; autoimmune diseases, nervous system degradation IDUN PHARMACEUTICALS, INC. 2003-04-08 US disclosed
US-6534114-B2 Uses multi-slot coating apparatus to apply multiple liquid layers to moving substrate; high speed, for photographic film and paper products EASTMAN KODAK COMPANY 2003-03-18 US disclosed
US-6531467-B2 Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors IDUN PHARMACEUTICALS, INC. 2003-03-11 US disclosed
US-6528506-B2 Viability of organs transplants IDUN PHARMACEUTICALS, INC. 2003-03-04 US disclosed
US-20030039661-A1 Methods, compositions and kits for preserving antigenicity IDUN PHARMACEUTICALS, INC. 2003-02-27 US disclosed
US-20030004308-A1 Novel thrombin inhibitors, the preparation and use thereof BOHM HANS-JOACHIM (DE) 2003-01-02 US disclosed
EP-1270557-A1 ETHYLENEDIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2003-01-02 EP disclosed
CN-1382135-A Amine and amide derivatives as ligands for neuropeptide YY5 receptor usefu in treatment of obesity and other disorders ORTHO MCNEIL PHARM INC (US) 2002-11-27 CN disclosed
US-20020169318-A1 Novel thrombin inhibitors ABBVIE DEUTSCHLAND GMBH & CO KG (DE) 2002-11-14 US disclosed
CN-1378543-A Substituted pyridazines and fused pyridazines having angiogenesis inhibiting activity BAYER AG (US) 2002-11-06 CN disclosed
CN-1093859-C Novel indole-2,3-done-3-oxime derivatives NEUROSEARCH AS (DK) 2002-11-06 CN disclosed
US-20020160119-A1 Coating method EASTMAN KODAK COMPANY 2002-10-31 US disclosed
US-20020160120-A1 Coating method for modifying adhesion of thin films to substrates EASTMAN KODAK COMPANY 2002-10-31 US disclosed
US-20020147171-A1 Inhibition of apoptosis using interleukin-1beta converting enzyme (ICE)/CED-3 family inhibitors IDUN PHARMACEUTICALS, INC. (US) 2002-10-10 US disclosed
EP-0604352-B1 Aryl-substituted heterocyclic compounds NEUROSEARCH AS (DK) 2002-10-09 EP disclosed
EP-0906279-B1 PYRROLE DERIVATIVES HOFFMANN LA ROCHE (CH) 2002-10-02 EP disclosed
US-6455671-B1 COMPOUND FOR USE IN THE TREATMENT OF THROMBOSIS ABBOTT LABORATORIES 2002-09-24 US disclosed
EP-1212339-A4 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS INC (US) 2002-09-18 EP disclosed
US-20020128306-A1 Programmed cell death; expansion of hematopoietic cells, for prolonging viability of an organ for transplantation, and maintaining viability of cell lines used in bioproduction IDUN PHARMACEUTICALS, INC. 2002-09-12 US disclosed
WO-2002070544-A2 METHODS, COMPOSITIONS AND KITS FOR PRESERVING ANTIGENICITY IDUN PHARMACEUTICALS, INC. (US) 2002-09-12 WO disclosed
US-20020123522-A1 Inhibition of inflammation using interleukin-1beta-converting enzyme (ICE)/CED-3 family inhibitors IDUN PHARMACEUTICALS, INC. (US) 2002-09-05 US disclosed
US-6444663-B2 TREATMENT OF PATIENTS SUFFERING INFLAMMATORY, AUTOIMMUNE AND NEURODEGENERATIVE DISEASES, AND FOR THE PREVENTION OF ISCHEMIC INJURY. IDUN PHARMACEUTICALS, INC. 2002-09-03 US disclosed
US-6444817-B1 ANTICOAGULANTS ABBOTT LABORATORIES 2002-09-03 US disclosed
US-20020115715-A1 Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders DAX SCOTT L (US) 2002-08-22 US disclosed
EP-1228063-A2 SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY Bayer Corporation (US) 2002-08-07 EP disclosed
WO-2002057298-A2 C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES IDUN PHARMACEUTICALS, INC. (US) 2002-07-25 WO disclosed
US-20020091089-A1 (Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases KARANEWSKY DONALD S (US) 2002-07-11 US disclosed
EP-1212339-A1 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS, INC. (US) 2002-06-12 EP disclosed
EP-1208096-A1 SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY Bayer Corporation (US) 2002-05-29 EP disclosed
EP-1202986-A1 AMINE AND AMIDE DERIVATIVES AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS Ortho-McNeil Pharmaceutical, Inc. (US) 2002-05-08 EP disclosed
US-6380224-B1 FOR THERAPY OF EATING DISORDERS, OBESITY, BULIMIA NERVOSA, DIABETES, MEMORY LOSS, EPILEPTIC SEIZURES, MIGRAINE, SLEEP DISTURBANCES, PAIN, SEXUAL/REPRODUCTIVE DISORDERS, DEPRESSION AND ANXIETY ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-04-30 US disclosed
US-20020042376-A1 C-terminal modified oxamyl dipeptides as inhibitors of the ICE-ced-3 family of cysteine proteases CONATUS PHARMACEUTICALS, INC. 2002-04-11 US disclosed
EP-0874850-B1 NOVEL TRICYCLIC COMPOUNDS FOR THE INHIBITION OF THE ICE/CED-3 PROTEASE FAMILY OF ENZYMES IDUN PHARMACEUTICALS INC (US) 2002-04-10 EP disclosed
US-20020028774-A1 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases CONATUS PHARMACEUTICALS, INC. 2002-03-07 US disclosed
US-20020016321-A1 Novel tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes KARANEWSKY DONALD S (US) 2002-02-07 US disclosed
WO-2002005860-A1 RADIOLIGAND AND BINDING ASSAY MERCK & CO., INC. (US) 2002-01-24 WO disclosed
US-20010044415-A1 Inhibition of apoptosis using interleukin-1B-converting enzyme (ICE)/CED-3 family inhibitors FRITZ LAWRENCE C (US) 2001-11-22 US disclosed
US-6297258-B1 USEFUL AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE. AMERICAN CYANAMID COMPANY 2001-10-02 US disclosed
CN-1313846-A C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cystenine proteases IDUN PHARMACEUTICALS INC (US) 2001-09-19 CN disclosed
US-6288082-B1 COMPOUNDS SUCH AS 6,7-DIETHOXY-4-(INDAN-5-YLAMINO) -QUINOLINE-3-CARBONITRILE USED AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYCSTIC KIDNEY DISEASE AMERICAN CYANAMID COMPANY 2001-09-11 US disclosed
EP-0929311-A4 INHIBITION OF APOPTOSIS USING INTERLEUKIN-1 beta-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS IDUN PHARMACEUTICALS INC (US) 2001-08-29 EP disclosed
EP-1123272-A1 (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES Idun Pharmaceuticals, Inc. (US) 2001-08-16 EP disclosed
EP-1118616-A1 Process for the production of 5'-nor-anhydrovinblastine ditartrate from plants of genus catharanthus Eriochem, S.A. (AR) 2001-07-25 EP disclosed
EP-1117659-A1 SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS American Cyanamid Company (US) 2001-07-25 EP disclosed
US-6242422-B1 (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases IDUN PHARMACUETICALS, INC. 2001-06-05 US disclosed
US-6239128-B1 COMBATING DISEASES AND DISORDERS ASSOCIATED WITH OR MEDIATED BY THE RELEASE OF EXCITATORY AMINO ACIDS, ASSOCIATED WITH REDUCED BLOOD FLOW TO THE BRAIN AND OTHER CNS TISSUE, NEUROSEARCH A/S (DK) 2001-05-29 US disclosed
WO-2001023375-A2 SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY BAYER CORPORATION (US) 2001-04-05 WO disclosed
US-6200969-B1 CONTACTING CELLS WITH REAGENT WHICH SUPPRESSES PROTEASE ACTIVITY OF INTERLEUKIN-1.BETA.-CONVERTING ENZYME (ICE)/CED-3 FAMILY, INHIBITING APOPTOSIS IN CELL POPULATION TO EXPANDING OR INCREASING SURVIVAL OF CELL POPULATION IDUN PHARMACEUTICALS, INC. 2001-03-13 US disclosed
US-6197750-B1 ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS IDUN PHARMACEUTICALS, INC. 2001-03-06 US disclosed
WO-2001014400-A1 2'-O-ACETAMIDO MODIFIED MONOMERS AND OLIGOMERS ISIS PHARMACEUTICALS, INC. (US) 2001-03-01 WO disclosed
WO-2001010859-A1 SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY BAYER CORPORATION (US) 2001-02-15 WO disclosed
US-6187771-B1 Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes IDUN PHARMACEUTICALS, INC. 2001-02-13 US disclosed
WO-2001009120-A1 AMINE AND AMIDE DERIVATIVES AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2001-02-08 WO disclosed
EP-1066037-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES FOR THERAPEUTIC USE NEUROSEARCH A/S (DK) 2001-01-10 EP disclosed
US-6136844-A ANTIINFLAMMATORY AGENT; AUTOIMMUNE DISEASE SYNTEX (U.S.A.) INC. (US) 2000-10-24 US disclosed
US-6127402-A AN INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE AND ARE ANTI-INFLAMMATORY AND ANALGESIC AGENTS SYNTEX (U.S.A.) INC. (US) 2000-10-03 US disclosed
US-6124285-A Indole-2,3-dione-3-oxime derivatives NEUROSEARCH A/S (DK) 2000-09-26 US disclosed
EP-0604355-B1 Akyl Substituted heterocyclic compounds NEUROSEARCH AS (DK) 2000-08-09 EP disclosed
EP-1023316-A2 METHODS AND COMPOSITIONS FOR LIPIDIZATION OF HYDROPHILIC MOLECULES UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2000-08-02 EP disclosed
US-6093692-A FATTY ACID DERIVATIVES OF DISULFIDE-CONTAINING COMPOUNDS SUCH AS DISULFIDE-CONTAINING PEPTIDES OR PROTEINS) COMPRISING FATTY ACID-CONJUGATED PRODUCTS WITH A DISULFIDE LINKAGE; IMPROVING BIOAVAILABILITY OF PEPTIDES, PROTEINS THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2000-07-25 US disclosed
US-6080859-A 1-CHLOROMETHYL, 3-((HETEROARYL OR ARYL)CARBONYL), 5-(HETEROCYCLE-AMINOCARBONYLOXY),7-TRIFLUOROMETHYL, 8-ALKOXYCARBONYL-1,2,3,6-TETRAHYDROPYRROLO(3,2-E)INDOLE OF GIVEN STRUCTURE; ANTITUMOR AND ANTIMICROBIAL ACTIVITY KYORIN PHARMACEUTICAL CO., LTD. (JP) 2000-06-27 US disclosed
WO-2000023421-A1 (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES IDUN PHARMACEUTICALS, INC. (US) 2000-04-27 WO disclosed
WO-2000018761-A1 SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS AMERICAN CYANAMID COMPANY (US) 2000-04-06 WO disclosed
US-6043248-A VIRICIDES FOR TREATING AN INDIVIDUAL INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS PHARMACIA & UPJOHN COMPANY (US) 2000-03-28 US disclosed
US-6030972-A 2- OR 5-AMINOMETHYL,2- OR 5-CYANOPYRIMIDINES AS INTERMEDIATES OF ANTICOAGULANTS IN EXTRACORPOREAL CIRCULATION (HEART-LUNG MACHINE, HEMODIALYSIS) BASF AKTIENGESELLSCHAFT (DE) 2000-02-29 US disclosed
EP-0972775-A1 PYRROLOINDOLE DERIVATIVES AND INTERMEDIATES IN PRODUCING THE SAME KYORIN PHARMACEUTICAL CO., LTD. (JP) 2000-01-19 EP disclosed
EP-0781284-B1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE NEUROSEARCH AS (DK) 2000-01-12 EP disclosed
EP-0781285-B1 FUSED INDOLE AND QUINOXALINE DERIVATIVES, THEIR PREPARATION AND USE AS GLUTAMATE ANTAGONISTS NEUROSEARCH AS (DK) 2000-01-12 EP disclosed
US-5968927-A AZEPINO-INDOLE COMPOUNDS; TREATMENT OF INFLAMMATORY, AUTOIMMUNE AND NEURODEGENERATIVE DISEASES, PREVENTION OF ISCHEMIC INJURY IDUN PHARMACEUTICALS, INC. (US) 1999-10-19 US disclosed
WO-1999049864-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES FOR THERAPEUTIC USE NEUROSEARCH A/S (DK) 1999-10-07 WO disclosed
US-5952368-A AN INHIBITORS OF PROSTAGLANDIN G/H SYNTHASE, ANTIINFLAMMATORY AND ANALGESIC AGENTS SYNTEX (U.S.A.) INC. (US) 1999-09-14 US disclosed
CN-1225629-A Novel pyrrole derivatives HOFFMANN LA ROCHE (CH) 1999-08-11 CN disclosed
US-5929084-A Huperzine A derivatives, their preparation and their use SHANGAHI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES (CN) 1999-07-27 US disclosed
EP-0929311-A1 INHIBITION OF APOPTOSIS USING INTERLEUKIN-1 beta-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS Idun Pharmaceuticals, Inc. (US) 1999-07-21 EP disclosed
US-5917053-A INHIBITING GABA RELEASE FROM NEURONS NEUROSEARCH A/S (DK) 1999-06-29 US disclosed
EP-0906279-A1 NOVEL PYRROLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-04-07 EP disclosed
CN-1207100-A Novel indole-2,3-done-3-oxime derivatives NEUROSEARCH AS (DK) 1999-02-03 CN disclosed
CN-1207101-A Novel tricyclic compounds for the inhibition of the ice/ced-3 protease family of enzymes IDUM PHARMACEUTICALS INC (US) 1999-02-03 CN disclosed
US-5849510-A Factor Xa inhibitors SELECTIDE CORPORATION (US) 1998-12-15 US disclosed
US-5843945-A AMPA antagonists and a method of treatment NEUROSEARCH A/S (DK) 1998-12-01 US disclosed
EP-0869958-A1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH A/S (DK) 1998-10-14 EP disclosed
US-5801174-A CEREBROVASCULAR DISORDERS NEUROSEARCH A/S (DK) 1998-09-01 US disclosed
WO-1998013007-A9 METHODS AND COMPOSITIONS FOR LIPIDIZATION OF HYDROPHILIC MOLECULES 1998-08-13 WO disclosed
US-5780493-A TREATING BRAIN DISORDERS NEUROSEARCH A/S (DK) 1998-07-14 US disclosed
CN-1183773-A Alpha-substituted pyrimidine-thioalkyl and alkylether compounds UPJOHN CO (US) 1998-06-03 CN disclosed
US-5739149-A TREATING ASTHMA ZENECA LIMITED (GB) 1998-04-14 US disclosed
WO-1998014447-A1 NOVEL INDOLE-2,3-DIONE-3-OXIME DERIVATIVES NEUROSEARCH A/S (DK) 1998-04-09 WO disclosed
WO-1998013007-A2 METHODS AND COMPOSITIONS FOR LIPIDIZATION OF HYDROPHILIC MOLECULES UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1998-04-02 WO disclosed
WO-1998010778-A1 INHIBITION OF APOPTOSIS USING INTERLEUKIN-1β-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS IDUN PHARMACEUTICALS, INC. (US) 1998-03-19 WO disclosed
EP-0824524-A1 ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE PHARMACIA &amp; UPJOHN COMPANY (US) 1998-02-25 EP disclosed
EP-0698025-B1 AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH NEUROSEARCH AS (DK) 1997-12-17 EP disclosed
WO-1997046524-A1 NOVEL PYRROLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1997-12-11 WO disclosed
US-5663154-A VIRICIDES, HIV, HEPATITIS GLAXO WELLCOME INC. (US) 1997-09-02 US disclosed
EP-0781284-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE NEUROSEARCH A/S (DK) 1997-07-02 EP disclosed
US-5635509-A ASTHMA; BRONCHODILATOR AGENTS; VASODILATION MICROVASCULAR PERMEABILITY; MAST CELLS ZENECA LIMITED (GB) 1997-06-03 US disclosed
EP-0758341-A1 FACTOR Xa INHIBITORS SELECTIDE CORPORATION (US) 1997-02-19 EP disclosed
WO-1996035678-A1 ALPHA-SUBSTITUTED PYRIMIDINE-THIOALKYL AND ALKYLETHER COMPOUNDS AS INHIBITORS OF VIRAL REVERSE TRANSCRIPTASE PHARMACIA & UPJOHN COMPANY (US) 1996-11-14 WO disclosed
US-5559249-A 7'-amino-naphthazarin antibiotic derivatives GRUPPO LEPETIT SPA (IT) 1996-09-24 US disclosed
US-5554626-A TREATMENT OF PARKINSON*S DISEASE, DRUG ABUSE/DEPENDENCE; COANIE/AMPHETAMINE ADDICTION NEUROSEARCH A/S (DK) 1996-09-10 US disclosed
US-5530133-A VAGINAL INFECTIONS GRUPPO LEPETIT SPA (IT) 1996-06-25 US disclosed
EP-0641346-B1 7'-AMINO-NAPHTHAZARIN ANTIBIOTIC DERIVATIVES LEPETIT SPA (IT) 1996-05-29 EP disclosed
WO-1996008494-A1 INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE NEUROSEARCH A/S (DK) 1996-03-21 WO disclosed
WO-1996008495-A1 FUSED INDOLE AND QUINOXALINE DERIVATIVES, THEIR PREPARATION AND USE NEUROSEARCH A/S (DK) 1996-03-21 WO disclosed
EP-0698025-A1 AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH NEUROSEARCH A/S (DK) 1996-02-28 EP disclosed
EP-0445731-B1 Azabicyclo and azacyclo oxime and amine cholinergic agents and pharmaceutically acceptable salts thereof WARNER LAMBERT CO (US) 1996-01-10 EP disclosed
EP-0680962-A2 Heterocyclic compounds ZENECA LIMITED (GB) 1995-11-08 EP disclosed
WO-1995029189-A1 FACTOR Xa INHIBITORS SELECTIDE CORPORATION (US) 1995-11-02 WO disclosed
US-5444070-A TREATING A DISEASE OR DISORDER WHICH IS RESPONSIVE TO THE INHIBITION OF DOPAMINE REUPTAKE BY ADMINISTERING A TROPANE DERIVATIVE NEUROSEARCH A/S (DK) 1995-08-22 US disclosed
EP-0641346-A1 7'-AMINO-NAPHTHAZARIN ANTIBIOTIC DERIVATIVES. LEPETIT SPA (IT) 1995-03-08 EP disclosed
US-5384319-A Interleukin inhibitors; analgesics CIBA-GEIGY CORPORATION (US) 1995-01-24 US disclosed
EP-0394989-B1 Peptide compounds, process for preparation thereof and pharmaceutical composition comprising the same FUJISAWA PHARMACEUTICAL CO (JP) 1994-12-21 EP disclosed
US-5374636-A Antidrug abuse, antidepressants, antiParkinson activity NEUROSEARCH A/S (DK) 1994-12-20 US disclosed
US-5369113-A Certain 2,3-diphenyl-2-(1,2,4-oxadiazol-5-yl)tropanes useful as dopamide reuptake inhibitors NEUROSEARCH A/S (DK) 1994-11-29 US disclosed
WO-1994026747-A1 AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH NEUROSEARCH A/S (DK) 1994-11-24 WO disclosed
EP-0625158-A1 THERAPEUTIC NUCLEOSIDES THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-23 EP disclosed
US-5332811-A Antitumor intermediates THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1994-07-26 US disclosed
EP-0604352-A2 Aryl substituted heterocyclic compounds NEUROSEARCH A/S (DK) 1994-06-29 EP disclosed
EP-0604355-A2 Akyl Substituted heterocyclic compounds NEUROSEARCH A/S (DK) 1994-06-29 EP disclosed
US-5306718-A Analgesics, cognition activators WARNER-LAMBERT COMPANY (US) 1994-04-26 US disclosed
WO-1993014103-A1 THERAPEUTIC NUCLEOSIDES THE WELLCOME FOUNDATION LIMITED (GB) 1993-07-22 WO disclosed
WO-1993012115-A1 7'-AMINO-NAPHTHAZARIN ANTIBIOTIC DERIVATIVES GRUPPO LEPETIT S.P.A. (IT) 1993-06-24 WO disclosed
US-5164372-A Treatment of respiratory disorders, inflammation, dermatitis FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1992-11-17 US disclosed
EP-0337765-B1 ACYLSULFONAMIDE DERIVATIVES OF ALPHA-CARBOCYCLYLTOLUIC ACIDS USED AS LEUKOTRIENE ANTAGONISTS ICI AMERICAS INC. (US) 1992-10-14 EP disclosed
US-5147867-A Bactericides, (carba)penicillins MERCK & CO., INC. (US) 1992-09-15 US disclosed
US-5145990-A Dehydropeptidase, carbapenicillin potentiation MERCK & CO., INC. (US) 1992-09-08 US disclosed
US-5138042-A 6-deoxyanthracyclines FARMITALIA CARLO ERBA S.P.A. (IT) 1992-08-11 US disclosed
US-5095038-A Antiinflammatory, antiallergens ICI AMERICAS INC. (US) 1992-03-10 US disclosed
US-5037970-A 6-deoxyanthracyclines FARMITALIA CARLO ERBA S.P.A. (IT) 1991-08-06 US disclosed
US-5021439-A Senile dementia and memory dysfunction TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1991-06-04 US disclosed
US-4980343-A Inhibit colon and rectal tumors BAYER AKTIENGESELLSCHAFT (DE) 1990-12-25 US disclosed
US-4968717-A SEROTONIN-AND CALCIUM-ANTAGONISTS BASF AKTIENGESELLSCHAFT (DE) 1990-11-06 US disclosed
US-4968790-A HYPOGLYCEMIC AGENTS, PLANT GROWTH REGULATORS AMERICAN CYANAMID COMPANY (US) 1990-11-06 US disclosed
EP-0394989-A2 Peptide compounds, process for preparation thereof and pharmaceutical composition comprising the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-10-31 EP disclosed
US-4966855-A SUBSTITUTED OXAZOLES OR THIAZOLES, FOR DETECTING HYDROGEN PEROXIDE BOEHRINGER MANNHEIM GMBH (DE) 1990-10-30 US disclosed
US-4962097-A IN COMBINATION WITH A CARBAPENEM OR PENEM ANTIBIOTIC MERCK & CO., INC. (US) 1990-10-09 US disclosed
US-4940780-A CARDIOVASCULAR DISORDERS, ASTHMA, ULCERS BASF AKTIENGESELLSCHAFT (DE) 1990-07-10 US disclosed
EP-0366469-A2 Phosphorus containing enzyme inhibitors MERCK & CO. INC. (US) 1990-05-02 EP disclosed
EP-0365956-A2 Carcinostatic agents BAYER AG (DE) 1990-05-02 EP disclosed
EP-0356223-A2 HIV protease inhibitors useful for the treatment of aids MERCK & CO. INC. (US) 1990-02-28 EP disclosed
EP-0337714-A2 HIV protease inhibitors useful for the treatment of aids MERCK & CO. INC. (US) 1989-10-18 EP disclosed
US-4755592-A Statine-containing peptides useful in medicaments MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1988-07-05 US disclosed
US-4746649-A Diamino acid derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1988-05-24 US disclosed
US-4668622-A Phenolsulphonphthaleinyl-β-D-galactosides and diagnostic agents containing them BOEHRINGER MANNHEIM GMBH (DE) 1987-05-26 US disclosed
EP-0210545-A2 Phosphorous containing enzyme inhibitors MERCK & CO. INC. (US) 1987-02-04 EP disclosed
EP-0209897-A2 Peptide enzyme inhibitors MERCK & CO. INC. (US) 1987-01-28 EP disclosed
EP-0209848-A2 Enzyme inhibitors MERCK & CO. INC. (US) 1987-01-28 EP disclosed
EP-0092352-B1 9-SUBSTITUTED CARBACYCLINS THE UPJOHN COMPANY (US) 1986-07-02 EP disclosed
US-4487960-A 9-Substituted carbacyclin analogs THE UPJOHN COMPANY (US) 1984-12-11 US disclosed
US-4446322-A Hydroxyl protected 3-(2-hydroxy-2-phenylethyl)-N-[(phenylamino)carbonyl]sydnone imine intermediates AMERICAN HOME PRODUCTS CORPORATION (US) 1984-05-01 US disclosed
EP-0092352-A1 9-Substituted carbacyclins THE UPJOHN COMPANY (US) 1983-10-26 EP disclosed
EP-0024924-B1 SYDNONIMINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AMERICAN HOME PRODUCTS CORPORATION (US) 1983-08-31 EP disclosed
WO-1982001187-A1 CNS STIMULANTS AMERICAN HOME PROD (US) 1982-04-15 WO disclosed
EP-0049604-A1 CNS stimulants AMERICAN HOME PRODUCTS CORPORATION (US) 1982-04-14 EP disclosed
US-4277609-A Sydnone imines AMERICAN HOME PRODUCTS CORPORATION (US) 1981-07-07 US disclosed
EP-0024924-A2 Sydnonimines, their preparation and pharmaceutical compositions containing them AMERICAN HOME PRODUCTS CORPORATION (US) 1981-03-11 EP disclosed
WO-1981000567-A1 SYDNONE IMINES AMERICAN HOME PROD (US) 1981-03-05 WO disclosed
US-3979395-A Process for the preparation of vincamine and other indole alkaloids BUSKINE S.A. (CH) 1976-09-07 US disclosed
US-3979395-A Process for the preparation of vincamine and other indole alkaloids BUSKINE S.A. (CH) 1976-09-07 US disclosed