Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 10/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 10/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418631 | 0.87 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL6031648 | 0.79 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL9095949 | 0.79 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL7471242 | 0.78 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL7797879 | 0.77 | SHMT2 (0.46) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL4931286 | 0.77 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL5598718 | 0.77 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| Hydrochloric Acid SCHEMBL8610408 | 0.76 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| Hydrochloric Acid SCHEMBL7503522 | 0.76 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DPDE2A | |
| SCHEMBL7495905 | 0.75 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994022855-A1 | NITROGEN-CONTAINING FUSED-HETEROCYCLE COMPOUNDS | EISAI CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |