Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.57 |
| ▸ | PDE5A | O76074 | 5/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
| ▸ | RHOA | P61586 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 7/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 7/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031648 | 0.87 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9095949 | 0.86 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL146298 | 0.86 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7417021 | 0.77 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7424627 | 0.77 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7914747 | 0.76 | PDE5A (0.55) | PDE5ATDP1 | |
| SCHEMBL7914801 | 0.73 | PDE5A (0.55) | PDE5APDE2A | |
| SCHEMBL149748 | 0.73 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| Hydrochloric Acid SCHEMBL7502602 | 0.72 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL5917668 | 0.72 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469016-B1 | VAGINAL, VULVAR AND/OR URETHRAL ADMINISTRATION OF A PHARMACEUTICAL FORMULATION CONTAINING A VASOACTIVE AGENT TO INCREASE VAGINAL LUBRICATION | VIVUS, INC. | 2002-10-22 | — | — | US | claimed |
| US-20070225217-A1 | Methods, compositions, and kits for the treatment of medical conditions | COMBINATORX, INCORPORATED (US) | 2007-09-27 | — | — | US | disclosed |
| US-20030207852-A1 | Treatment of female sexual dysfunction | PLACE VIRGIL A (US) | 2003-11-06 | — | — | US | disclosed |
| US-6469016-B1 | VAGINAL, VULVAR AND/OR URETHRAL ADMINISTRATION OF A PHARMACEUTICAL FORMULATION CONTAINING A VASOACTIVE AGENT TO INCREASE VAGINAL LUBRICATION | VIVUS, INC. | 2002-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225217-A1 | Methods, compositions, and kits for the treatment of medical conditions | TNF, PYGM, IL6 | PDE4A 458/4885PDE4B 709/4885PDE4C 471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.