Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 7/20 | 0.44 |
| ▸ | MMP3 | P08254 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BMP1 | P13497 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427000 | 0.89 | MMP2 (0.53) | MEN1NPC1KMT2AMMP2MMP3 | |
| SCHEMBL6778466 | 0.88 | MEN1 (0.53) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL7423179 | 0.83 | MEN1 (0.46) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL10816014 | 0.82 | SMN1; SMN2 (0.51) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL10816013 | 0.82 | SMN1; SMN2 (0.51) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL31516106 | 0.81 | GRIK1 (0.46) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL1857414 | 0.81 | SMN1; SMN2 (0.48) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL12265854 | 0.80 | KMT2A (0.59) | MEN1NPC1KMT2AGRIK1MMP2 | |
| SCHEMBL7427195 | 0.80 | SMN1; SMN2 (0.50) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL31516059 | 0.80 | HSD17B10 (0.53) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350885-B1 | TREATMENT OF MULTIPLE SCLEROSIS, ATHEROSCLEROTIC PLAQUE RUPTURE, AORTIC ANEURYSM, HEART FAILURE, LEFT VENTRICULAR DILATION, RESTENOSIS, PERIODONTAL DISEASE, CORNEAL ULCERATION, TREATMENT OF BURNS, DECUBITAL ULCERS, WOUND HEALING AGENT | WARNER-LAMBERT COMPANY | 2002-02-26 | — | — | US | disclosed |
| WO-2000006560-A1 | TRICYCLIC HETEROAROMATICS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |