Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10816014 | 0.93 | SMN1; SMN2 (0.51) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL10816013 | 0.93 | SMN1; SMN2 (0.51) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL1857414 | 0.91 | SMN1; SMN2 (0.48) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL7427000 | 0.91 | MMP2 (0.53) | MEN1NPC1KMT2A | |
| SCHEMBL18065697 | 0.90 | SMN1; SMN2 (0.57) | MEN1NPC1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL11269284 | 0.89 | SMN1; SMN2 (0.51) | MEN1NPC1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7424705 | 0.88 | MEN1 (0.49) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL11071293 | 0.88 | MAPT (0.51) | MEN1NPC1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL31516106 | 0.88 | GRIK1 (0.46) | MEN1NPC1KMT2AGRIK1SMN1; SMN2 | |
| SCHEMBL11071296 | 0.88 | MAPT (0.51) | MEN1NPC1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818643-B1 | 3,9-DIAZABICYCLO(3.3.1)NONAN-2-ONE DERIVATIVES; PEPTIDYL-PROLYL ISOMERASE (PPIASE OR ROTAMASE) INHIBITORS; NEUROPROTECTIVE AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-16 | — | — | US | disclosed |
| WO-2001042245-A1 | NEUROTROPHIC BICYCLIC DIAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |