Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 3/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433897 | 0.88 | GBA1 (0.42) | GBA1GRM2KDM4EALDH1A1GLS | |
| SCHEMBL3515320 | 0.80 | CYP11B1 (0.41) | GBA1GRM2KDM4EALDH1A1GLS | |
| SCHEMBL10461384 | 0.80 | GBA1 (0.48) | GBA1GRM2KDM4EALDH1A1GLS | |
| SCHEMBL14157125 | 0.79 | — | — | |
| SCHEMBL2358386 | 0.78 | GBA1 (0.47) | GBA1KDM4EALDH1A1ADRA2AADRA2B | |
| SCHEMBL4768617 | 0.78 | ADRA2A (0.39) | GBA1GRM2KDM4EALDH1A1GLS | |
| SCHEMBL14127790 | 0.77 | KCNH2 (0.48) | GBA1KDM4EALDH1A1ADRA2ARAB9A | |
| SCHEMBL22748383 | 0.77 | KCNH2 (0.48) | GBA1KDM4EALDH1A1ADRA2ARAB9A | |
| SCHEMBL9083017 | 0.77 | KCNH2 (0.48) | GBA1KDM4EALDH1A1ADRA2ARAB9A | |
| SCHEMBL9082300 | 0.77 | KCNH2 (0.48) | GBA1KDM4EALDH1A1ADRA2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | claimed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | claimed |
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | disclosed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | disclosed |