Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 14/20 | 0.58 |
| ▸ | CTSS | P25774 | 14/20 | 0.58 |
| ▸ | CTSK | P43235 | 6/20 | 0.45 |
| ▸ | CTSB | P07858 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359753 | 0.89 | CTSL (0.63) | CTSLCTSSCTSKCTSBUSP30 | |
| SCHEMBL5359608 | 0.87 | CTSL (0.61) | CTSLCTSSCTSKCTSBUSP30 | |
| SCHEMBL5372339 | 0.84 | CTSL (0.64) | CTSLCTSSCTSKCTSBUSP30 | |
| SCHEMBL5363304 | 0.84 | CTSS (0.57) | CTSLCTSSCTSKCTSBUSP30 | |
| SCHEMBL5363257 | 0.82 | CTSS (0.55) | CTSLCTSSCTSKCTSBUSP30 | |
| SCHEMBL5374901 | 0.79 | CTSS (0.71) | CTSLCTSSCTSKCTSB | |
| SCHEMBL5365222 | 0.78 | CTSS (0.64) | CTSLCTSSCTSKCTSB | |
| SCHEMBL5361155 | 0.78 | CTSS (0.79) | CTSLCTSSCTSB | |
| SCHEMBL5357750 | 0.78 | CTSL (0.66) | CTSLCTSSCTSKCTSB | |
| SCHEMBL5365047 | 0.78 | CTSL (0.66) | CTSLCTSSCTSKCTSBUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |