Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428420 | 0.91 | MET (0.47) | METRAB9ALMNATSHRNFKB1 | |
| SCHEMBL7433220 | 0.87 | MET (0.49) | METHCRTR1HCRTR2KMT2AL3MBTL1 | |
| SCHEMBL7421328 | 0.85 | MET (0.52) | METHCRTR1HCRTR2KMT2AL3MBTL1 | |
| SCHEMBL7424903 | 0.83 | ALOX5AP (0.49) | METHCRTR1HCRTR2KMT2AL3MBTL1 | |
| SCHEMBL7424860 | 0.83 | HCRTR1 (0.50) | METRAB9ALMNATSHRNFKB1 | |
| SCHEMBL7429461 | 0.80 | MET (0.50) | METHCRTR1HCRTR2KMT2AL3MBTL1 | |
| SCHEMBL783030 | 0.76 | LMNA (0.65) | RAB9ALMNATSHRNFKB1NFKB2 | |
| SCHEMBL7429033 | 0.76 | ALOX5AP (0.48) | METHCRTR1HCRTR2KMT2AL3MBTL1 | |
| SCHEMBL7421333 | 0.76 | MET (0.53) | METLMNAHCRTR1HCRTR2KMT2A | |
| SCHEMBL7428425 | 0.76 | MET (0.47) | METLMNAHCRTR1HCRTR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |