Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 13/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.48 |
| ▸ | TPSD1 | Q9BZJ3 | 7/20 | 0.48 |
| ▸ | TPSG1 | Q9NRR2 | 7/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7436446 | 0.93 | TPSAB1 (0.47) | TPSAB1MEN1KMT2APRSS1TPSD1 | |
| SCHEMBL7506036 | 0.86 | TPSAB1 (0.65) | TPSAB1MEN1KMT2APRSS1TPSD1 | |
| SCHEMBL7499097 | 0.85 | TPSAB1 (0.66) | TPSAB1MEN1KMT2APRSS1TPSD1 | |
| SCHEMBL7508800 | 0.85 | TPSAB1 (0.66) | TPSAB1MEN1KMT2APRSS1TPSD1 | |
| SCHEMBL7570914 | 0.85 | TPSAB1 (0.66) | TPSAB1MEN1KMT2APRSS1TPSD1 | |
| SCHEMBL7504794 | 0.85 | TPSAB1 (0.66) | TPSAB1MEN1KMT2APRSS1TPSD1 | |
| SCHEMBL7419017 | 0.83 | TPSAB1 (0.42) | TPSAB1MEN1KMT2APRSS1TPSD1 | |
| SCHEMBL7452362 | 0.83 | TPSAB1 (0.48) | TPSAB1MEN1KMT2APRSS1TPSD1 | |
| SCHEMBL7447705 | 0.83 | TPSAB1 (0.67) | TPSAB1PRSS1TPSD1TPSG1F2 | |
| SCHEMBL7419019 | 0.82 | MEN1 (0.52) | TPSAB1MEN1KMT2APRSS1TPSD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | disclosed |