Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 17/20 | 0.66 |
| ▸ | TPSD1 | Q9BZJ3 | 11/20 | 0.66 |
| ▸ | TPSG1 | Q9NRR2 | 11/20 | 0.66 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.66 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570914 | 1.00 | TPSAB1 (0.66) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7504794 | 1.00 | TPSAB1 (0.66) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7508800 | 1.00 | TPSAB1 (0.66) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7506036 | 0.99 | TPSAB1 (0.65) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7446634 | 0.97 | TPSAB1 (0.62) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7506910 | 0.97 | TPSAB1 (0.62) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7447350 | 0.97 | TPSAB1 (0.62) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7444963 | 0.91 | TPSAB1 (0.56) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7424872 | 0.85 | TPSAB1 (0.53) | TPSAB1TPSD1TPSG1PRSS1PRSS2 | |
| SCHEMBL7554479 | 0.83 | TPSAB1 (0.53) | TPSAB1TPSD1TPSG1PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |