Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433223 | 0.95 | MET (0.50) | SLC6A4METHCRTR1HCRTR2SPHK2 | |
| SCHEMBL7429033 | 0.84 | ALOX5AP (0.48) | SLC6A4METHCRTR1HCRTR2HDAC1 | |
| SCHEMBL7424903 | 0.83 | ALOX5AP (0.49) | SLC6A4METHCRTR1HCRTR2HDAC1 | |
| SCHEMBL7428425 | 0.83 | MET (0.47) | METHCRTR1HCRTR2HDAC1HDAC6 | |
| SCHEMBL7424860 | 0.83 | HCRTR1 (0.50) | SLC6A4METHCRTR1HCRTR2ALOX5AP | |
| SCHEMBL7421333 | 0.80 | MET (0.53) | METHCRTR1HCRTR2HDAC1HDAC6 | |
| SCHEMBL7429461 | 0.79 | MET (0.50) | SLC6A4METHCRTR1HCRTR2HDAC1 | |
| SCHEMBL7428369 | 0.78 | P2RX3 (0.43) | METHCRTR1HCRTR2HDAC1HDAC6 | |
| SCHEMBL7433220 | 0.78 | MET (0.49) | SLC6A4METHCRTR1HCRTR2HDAC1 | |
| SCHEMBL7424354 | 0.78 | SLC6A4 (0.42) | SLC6A4METHCRTR1HCRTR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |