SCHEMBL7424967

SCHEMBL7424967

CCOC(=O)CCN1CC(=O)N(CC(C)C)c2ccc(O)cc2C1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
TNF P01375 3/20 0.37
TRPA1 O75762 1/20 0.36
PIN1 Q13526 1/20 0.36
PIN4 Q9Y237 1/20 0.36
KDM4E B2RXH2 1/20 0.36
GLA P06280 1/20 0.36
GAA P10253 1/20 0.36
HPGD P15428 1/20 0.36
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7363500 0.90 ALDH1A1 (0.41) ALDH1A1TNFPIN1PIN4KDM4E
SCHEMBL7539270 0.86 MAPT (0.41) ALDH1A1KDM4EHPGDCASP1CASP7
SCHEMBL7321392 0.86 TNF (0.38) ALDH1A1TNFKDM4EGLAGAA
SCHEMBL7332526 0.85 ITGB3 (0.46) ALDH1A1TNFKDM4EGLAGAA
SCHEMBL7355386 0.85 ALDH1A1 (0.38) ALDH1A1TNFPIN1PIN4KDM4E
SCHEMBL7419551 0.83 ALDH1A1 (0.41) ALDH1A1TNFPIN1PIN4KDM4E
SCHEMBL7357541 0.82 BRD4 (0.41) ALDH1A1TNFMEN1KMT2AITGB3
SCHEMBL7361234 0.81 MAOB (0.39) ITGB3ITGA2BS1PR1RAB9AGABRG2
SCHEMBL7331027 0.81 ITGB3 (0.61) TNFITGB3ITGA2BGABRG2GABRB3
SCHEMBL7425545 0.81 BRD4 (0.40) ALDH1A1TNFITGB3ITGA2BGABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5674863-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5674865-A BENZODIAZEPINEDIONE DERIVATIVE; FIBRINOGIN BINDING INHIBITOR GENENTECH, INC. (US) 1997-10-07 US disclosed
US-5663166-A ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING GENENTECH, INC. (US) 1997-09-02 US disclosed
US-5565449-A PLATELET AGGREGATION INHIBITORS GENENTECH, INC. (US) 1996-10-15 US disclosed
EP-0610334-B1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR GENENTECH INC (US) 1996-01-24 EP disclosed
WO-1993008174-A1 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR GENENTECH, INC. (US) 1993-04-29 WO disclosed