Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3096665 | 0.81 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1 | |
| SCHEMBL31207339 | 0.80 | ALDH1A1 (0.57) | MEN1KMT2AMAOBALDH1A1POLB | |
| SCHEMBL6692120 | 0.78 | ALDH1A1 (0.56) | MEN1KMT2AMAOBALDH1A1POLB | |
| SCHEMBL2672326 | 0.78 | MEN1 (0.47) | MEN1KMT2APOLBCYP2C19 | |
| Acetamide SCHEMBL4985827 | 0.77 | L3MBTL1 (0.52) | MEN1KMT2AMAOBALDH1A1POLB | |
| SCHEMBL7420624 | 0.76 | KDM4A (0.54) | MEN1KMT2AMAOBALDH1A1KDM4A | |
| SCHEMBL6773482 | 0.76 | KDM4A (0.54) | MEN1KMT2AMAOBALDH1A1KDM4A | |
| SCHEMBL30619954 | 0.76 | L3MBTL1 (0.56) | MEN1KMT2AMAOBALDH1A1POLB | |
| SCHEMBL1572954 | 0.76 | L3MBTL1 (0.56) | MEN1KMT2AMAOBALDH1A1POLB | |
| SCHEMBL960746 | 0.75 | L3MBTL1 (0.53) | MEN1KMT2AMAOBALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968198-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR INHIBITING $g(b)-AMYLOID PEPTIDE | Elan Pharmaceuticals, Inc. (US) | 2000-01-05 | — | — | EP | disclosed |
| EP-0951466-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998038177-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR INHIBITING β-AMYLOID PEPTIDE | ELAN PHARMACEUTICALS, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1998028268-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AS β-AMYLOID PEPTIDE RELEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 1998-07-02 | — | — | WO | disclosed |