SCHEMBL7425440

SCHEMBL7425440

COc1cc(C(CC2CCN(CCC(=O)O)CC2)NC(C)=O)ccc1NC(=O)Nc1ccccc1C

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 10/20 0.44
ITGA4 P13612 10/20 0.44
THRB P10828 1/20 0.42
CCR3 P51677 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
LMNA P02545 1/20 0.40
SIGMAR1 Q99720 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7392019 0.95 ITGA4 (0.43) ITGB1ITGA4THRBCCR3MEN1
SCHEMBL7426910 0.95 ITGB1 (0.43) ITGB1ITGA4CCR3MEN1KMT2A
SCHEMBL7431427 0.92 ITGB1 (0.53) ITGB1ITGA4MEN1KMT2ANPSR1
SCHEMBL7539591 0.91 ITGA4 (0.42) ITGB1ITGA4CCR3MEN1KMT2A
SCHEMBL7390518 0.89 ITGA4 (0.49) ITGB1ITGA4CCR3MEN1KMT2A
SCHEMBL7430152 0.88 ITGA4 (0.48) ITGB1ITGA4CCR3MEN1KMT2A
SCHEMBL7428883 0.87 ITGB1 (0.50) ITGB1ITGA4MEN1KMT2A
SCHEMBL7392261 0.87 THRB (0.47) ITGB1ITGA4THRBMEN1KMT2A
SCHEMBL7425026 0.86 ITGB1 (0.47) ITGB1ITGA4CCR3MEN1KMT2A
SCHEMBL7392319 0.85 ITGA4 (0.47) ITGB1ITGA4CCR3MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999054321-A1 SUBSTITUTED DIAMINES AND THEIR USE AS CELL ADHESION INHIBITORS AVENTIS PHARMA LIMITED (GB) 1999-10-28 WO disclosed