Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 13/20 | 0.41 |
| ▸ | EDNRB | P24530 | 10/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427422 | 0.92 | NPC1 (0.37) | EDNRAEDNRBSLC22A12HPGD | |
| SCHEMBL7419283 | 0.90 | SMN1; SMN2 (0.41) | EDNRAEDNRBSLC22A12HPGDKDM4E | |
| SCHEMBL7417956 | 0.84 | ALOX5AP (0.48) | OXER1ALDH1A1HPGDKDM4E | |
| SCHEMBL7424082 | 0.83 | SLC22A12 (0.42) | EDNRAEDNRBSLC22A12ALDH1A1HPGD | |
| SCHEMBL7424721 | 0.82 | SLC22A12 (0.57) | EDNRAEDNRBSLC22A12ALDH1A1HPGD | |
| SCHEMBL7427199 | 0.80 | SLC22A12 (0.47) | EDNRAEDNRBSLC22A12ALDH1A1HPGD | |
| SCHEMBL7422706 | 0.80 | SLC22A12 (0.41) | EDNRAEDNRBSLC22A12ALDH1A1MAPK1 | |
| SCHEMBL7423832 | 0.78 | SLC22A12 (0.46) | EDNRAEDNRBSLC22A12ALDH1A1HPGD | |
| SCHEMBL7418814 | 0.77 | OXER1 (0.41) | SLC22A12OXER1ALDH1A1MAPK1 | |
| SCHEMBL7427533 | 0.76 | ALOX5AP (0.46) | SLC22A12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| CN-1187812-A | Indole derivatives as CGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-07-15 | — | — | CN | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |