Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 13/20 | 0.39 |
| ▸ | EDNRB | P24530 | 12/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429126 | 0.92 | MEN1 (0.40) | SLC22A12EDNRAALDH1A1MAPK1 | |
| SCHEMBL7426123 | 0.92 | SLC22A12 (0.39) | SLC22A12EDNRAEDNRBMAPK1 | |
| SCHEMBL7424082 | 0.88 | SLC22A12 (0.42) | SLC22A12EDNRAEDNRBALDH1A1MAPK1 | |
| SCHEMBL8553745 | 0.83 | PPARG (0.36) | SLC22A12FABP4 | |
| SCHEMBL7423537 | 0.82 | MEN1 (0.40) | SLC22A12EDNRAALDH1A1MAPK1 | |
| SCHEMBL7420199 | 0.81 | SLC22A12 (0.37) | SLC22A12EDNRAEDNRB | |
| SCHEMBL7426853 | 0.80 | SLC22A12 (0.40) | SLC22A12EDNRAEDNRBALDH1A1MAPK1 | |
| SCHEMBL7425503 | 0.80 | EDNRA (0.41) | SLC22A12EDNRAEDNRBALDH1A1MAPK1 | |
| SCHEMBL7420896 | 0.78 | LMNA (0.40) | ALDH1A1MAPK1 | |
| SCHEMBL7418953 | 0.78 | EDNRA (0.39) | SLC22A12EDNRAEDNRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| CN-1187812-A | Indole derivatives as CGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-07-15 | — | — | CN | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |