Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 5/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425503 | 0.92 | EDNRA (0.41) | SLC22A12EDNRAEDNRBHPGD | |
| SCHEMBL7419283 | 0.90 | SMN1; SMN2 (0.41) | NPC1SLC22A12EDNRAEDNRBCYP1A2 | |
| SCHEMBL7421689 | 0.84 | ALOX5AP (0.49) | NPC1ALOX5APPLA2G2ACYP1A2CYP3A4 | |
| SCHEMBL7426853 | 0.84 | SLC22A12 (0.40) | SLC22A12CHEK2EDNRAEDNRBCYP1A2 | |
| SCHEMBL7427199 | 0.82 | SLC22A12 (0.47) | SLC22A12EDNRAPLA2G2AEDNRBCYP1A2 | |
| SCHEMBL7420199 | 0.81 | SLC22A12 (0.37) | SLC22A12CHEK2EDNRAPLA2G2AEDNRB | |
| SCHEMBL7418953 | 0.81 | EDNRA (0.39) | SLC22A12CHEK2EDNRAEDNRBCYP1A2 | |
| SCHEMBL7427382 | 0.80 | SLC22A12 (0.39) | SLC22A12CHEK2EDNRAEDNRBCYP1A2 | |
| SCHEMBL7426123 | 0.80 | SLC22A12 (0.39) | NPC1SLC22A12CHEK2EDNRAPLA2G2A | |
| SCHEMBL7424721 | 0.80 | SLC22A12 (0.57) | SLC22A12EDNRAALOX5APEDNRBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| CN-1187812-A | Indole derivatives as CGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-07-15 | — | — | CN | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |