Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.39 |
| ▸ | CDC25B | P30305 | 4/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870047 | 1.00 | MME (0.42) | MMEACECPA1ACE2MAPT | |
| SCHEMBL5869800 | 1.00 | MME (0.42) | MMEACECPA1ACE2MAPT | |
| SCHEMBL5869794 | 1.00 | MME (0.42) | MMEACECPA1ACE2MAPT | |
| SCHEMBL8248789 | 0.90 | KEAP1 (0.43) | MAPTKEAP1NFE2L2PTPN1PTPN2 | |
| SCHEMBL5869605 | 0.90 | KEAP1 (0.43) | MAPTKEAP1NFE2L2PTPN1PTPN2 | |
| SCHEMBL8255067 | 0.86 | KEAP1 (0.44) | ACEACE2MAPTKEAP1NFE2L2 | |
| SCHEMBL8249919 | 0.84 | MAPT (0.43) | MMEACECPA1ACE2MAPT | |
| SCHEMBL5870095 | 0.84 | MAPT (0.43) | MMEACECPA1ACE2MAPT | |
| SCHEMBL22491224 | 0.84 | PTGDR2 (0.36) | MMEACECPA1ACE2MAPT | |
| SCHEMBL22491217 | 0.84 | PGR (0.39) | MMEACECPA1ACE2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |