Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Carbazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.48 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | GPR3 | P46089 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | AHR | P35869 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | TNKS | O95271 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbazole SCHEMBL10650068 | 1.00 | ALDH1A1 (0.70) | ALDH1A1GPR3HSD17B10KDM4ELMNA | |
| Carbazole SCHEMBL16345387 | 0.91 | ALDH1A1 (0.64) | ALDH1A1GPR3HSD17B10KDM4ELMNA | |
| Carbazole SCHEMBL28689618 | 0.87 | ALDH1A1 (0.58) | ALDH1A1GPR3HSD17B10KDM4ELMNA | |
| Carbazole SCHEMBL28081524 | 0.85 | ALDH1A1 (0.70) | ALDH1A1GPR3HSD17B10KDM4ELMNA | |
| Carbazole SCHEMBL27801438 | 0.85 | ALDH1A1 (0.70) | ALDH1A1GPR3HSD17B10KDM4ELMNA | |
| Carbazole SCHEMBL17912282 | 0.85 | ALDH1A1 (0.56) | ALDH1A1GPR3HSD17B10KDM4ELMNA | |
| Carbazole SCHEMBL29627417 | 0.84 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10KDM4ELMNA | |
| Carbazole SCHEMBL30761795 | 0.84 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10KDM4ELMNA | |
| Carbazole SCHEMBL7650 | 0.84 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10KDM4ELMNA | |
| Carbazole SCHEMBL29355407 | 0.84 | ALDH1A1 (1.00) | ALDH1A1GPR3HSD17B10KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1234 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109628363-B | Engineering bacterium for producing high molecular weight hyaluronic acid and construction method and application thereof | 南开大学 | 2022-12-02 | — | — | CN | claimed |
| CN-113318125-B | Preparation method of echinacea polysaccharide nanoparticles | 青岛农业大学 | 2022-10-11 | — | — | CN | claimed |
| CN-113402633-B | Hyaluronic acid-superoxide dismutase conjugate and application thereof in skin care products | 山东大学 | 2022-04-05 | — | — | CN | claimed |
| CN-113402633-A | Hyaluronic acid-superoxide dismutase conjugate and application thereof in skin care products | 山东大学 | 2021-09-17 | — | — | CN | claimed |
| CN-113318125-A | Preparation method of echinacea polysaccharide nanoparticles | 青岛农业大学 | 2021-08-31 | — | — | CN | claimed |
| CN-110655588-A | Preparation method and application of Cladosiphon okamuranus polysaccharide | 上海辉文生物技术股份有限公司 | 2020-01-07 | — | — | CN | claimed |
| CN-109932446-A | A kind of detection method of Lycium barbarum polysaccharide extract | 苏州大学 | 2019-06-25 | — | — | CN | claimed |
| CN-109628363-A | One plant of engineering bacteria for producing high molecular weight hyaluronic acid and its construction method and application | 南开大学 | 2019-04-16 | — | — | CN | claimed |
| CN-108426880-A | A kind of method of bacteria alginate content in measurement sludge | 南开大学 | 2018-08-21 | — | — | CN | claimed |
| CN-107245114-A | The extraction of pectin and its content assaying method in a kind of silkworm excrement | 浙江理工大学 | 2017-10-13 | — | — | CN | claimed |
| US-4528188-A | Polysaccharide PS-A obtained from barrenwort deriving from plants belonging to the genus Epimedium, process for preparation thereof and phylactic and immunostimulating agents comprising said polysaccharide PS-A effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1985-07-09 | — | — | US | claimed |
| US-4514560-A | Aggregating polysaccharide derived from aureobacidium | SHINOHARA SATORU (JP) | 1985-04-30 | — | — | US | claimed |
| EP-0025123-B1 | POLYSACCHARIDE RBS SUBSTANCE, PROCESS FOR THE PRODUCTION THEREOF AND ANTITUMOR AGENT CONTAINING IT | SAPPORO BREWERIES LIMITED (JP) | 1984-07-25 | — | — | EP | claimed |
| EP-0086233-A1 | POLYSACCHARIDE PS-A ISOLATED FROM THE PLANT OF GENUS EPIMEDIUM VIOLACEUM MORR. ET DECNE., PROCESS FOR ITS PREPARATION, AND INFECTION-PREVENTING AGENT AND IMMUNOSTIMULATING AGENT CONTAINING THE POLYSACCHARIDE AS EFFECTIVE INGREDIENT | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1983-08-24 | — | — | EP | claimed |
| US-4396763-A | ANTITUMOR AGENTS | MEIJI MILK PRODUCTS COMPANY LIMITED (JP) | 1983-08-02 | — | — | US | claimed |
| US-4366308-A | PURIFICATION OF ANTITUMOR AGENT FROM RICE BRAN | SAPPORO BREWERIES LIMITED (JP) | 1982-12-28 | — | — | US | claimed |
| US-4357323-A | Polysaccharide RBS substance and antitumor agent containing same | SAPPORO BREWERIES LIMITED (JP) | 1982-11-02 | — | — | US | claimed |
| EP-0025123-A2 | Polysaccharide RBS substance, process for the production thereof and antitumor agent containing it | SAPPORO BREWERIES LIMITED (JP) | 1981-03-18 | — | — | EP | claimed |
| EP-0024206-A2 | Antitumor substance, composition comprising it and process for preparing said substance | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-02-25 | — | — | EP | claimed |
| US-4209507-A | CULTURING ACINETOBACTER CALCOACETICUS, IMMUNOSTIMULATORY ACTIVITY | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-06-24 | — | — | US | claimed |