Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | XBP1 | P17861 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425803 | 1.00 | NPSR1 (0.35) | NPSR1CYP1A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7427754 | 0.77 | ASF1A (0.38) | NPSR1CYP1A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7427758 | 0.77 | ASF1A (0.38) | NPSR1CYP1A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL872649 | 0.76 | ALDH1A1 (0.45) | NPSR1ALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL872650 | 0.76 | ALDH1A1 (0.45) | NPSR1ALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL7417031 | 0.73 | ATM (0.39) | NPSR1CYP1A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7417027 | 0.73 | ATM (0.39) | NPSR1CYP1A2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6935684 | 0.70 | ESR1 (0.43) | NPSR1CYP1A2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6440370 | 0.70 | NFE2L2 (0.43) | NPSR1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL6436169 | 0.70 | NFE2L2 (0.43) | NPSR1ALDH1A1SMN1; SMN2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5608069-A | TREATMENT OF NERVOUS SYSTEM DISORDERS WITH GAMMA-AMINOBUTYRIC ACID | NOVO NORDISK A/S (DK) | 1997-03-04 | — | — | US | disclosed |
| EP-0705246-A1 | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS THEREOF | NOVO NORDISK A/S (DK) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000483-A1 | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS THEREOF | NOVO NORDISK A/S (DK) | 1995-01-05 | — | — | WO | disclosed |