Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.62 |
| ▸ | MMP2 | P08253 | 15/20 | 0.61 |
| ▸ | MMP13 | P45452 | 10/20 | 0.61 |
| ▸ | MMP9 | P14780 | 9/20 | 0.61 |
| ▸ | MMP3 | P08254 | 7/20 | 0.61 |
| ▸ | MMP1 | P03956 | 6/20 | 0.61 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.59 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.59 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 3/20 | 0.59 |
| ▸ | MMP7 | P09237 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7391079 | 1.00 | KEAP1 (0.62) | KEAP1MMP2MMP13MMP9MMP3 | |
| SCHEMBL3120047 | 0.89 | SLC1A3 (0.60) | KEAP1MMP2MMP13MMP9MMP3 | |
| SCHEMBL7341150 | 0.89 | SLC1A3 (0.60) | KEAP1MMP2MMP13MMP9MMP3 | |
| SCHEMBL22234176 | 0.89 | SLC1A3 (0.60) | KEAP1MMP2MMP13MMP9MMP3 | |
| SCHEMBL13570627 | 0.88 | MMP2 (0.58) | KEAP1MMP2MMP13MMP9MMP3 | |
| SCHEMBL13570496 | 0.88 | MMP2 (0.58) | KEAP1MMP2MMP13MMP9MMP3 | |
| SCHEMBL13570499 | 0.87 | MMP2 (0.62) | MMP2MMP13MMP9MMP3MMP1 | |
| SCHEMBL13570807 | 0.87 | MMP2 (0.62) | MMP2MMP13MMP9MMP3MMP1 | |
| SCHEMBL4619626 | 0.87 | MMP2 (0.66) | MMP2MMP13MMP9MMP3MMP1 | |
| SCHEMBL4621504 | 0.87 | MMP2 (0.66) | MMP2MMP13MMP9MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923561-B1 | HETEROCYCLIC METALLOPROTEASE INHIBITORS | PROCTER & GAMBLE (US) | 2002-10-23 | — | — | EP | disclosed |
| US-6399598-B1 | ORAL DISEASES; RHEUMATIC DISEASES; OSTEOPOROSIS | THE PROCTER & GAMBLE COMPANY | 2002-06-04 | — | — | US | disclosed |
| US-6121258-A | FOR TREATMENT OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS, SKIN DISORDERS, OCULAR DISORDERS, INFLAMMATION, GUM DISEASE | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0923561-A1 | HETEROCYCLIC METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008823-A1 | HETEROCYCLIC METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |