Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 7/20 | 0.52 |
| ▸ | ACE | P12821 | 6/20 | 0.52 |
| ▸ | GPR34 | Q9UPC5 | 4/20 | 0.50 |
| ▸ | GRN | P28799 | 2/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 3/20 | 0.47 |
| ▸ | CPA1 | P15085 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870263 | 1.00 | ACE2 (0.52) | ACE2ACEGPR34GRNSORT1 | |
| SCHEMBL5869463 | 1.00 | ACE2 (0.52) | ACE2ACEGPR34GRNSORT1 | |
| SCHEMBL22491211 | 0.89 | CTSS (0.46) | ACE2ACEGPR34FFAR1 | |
| SCHEMBL5869311 | 0.88 | ACE2 (0.52) | ACE2ACEGPR34GRNSORT1 | |
| SCHEMBL8250026 | 0.88 | ACE2 (0.52) | ACE2ACEGPR34GRNSORT1 | |
| SCHEMBL5870561 | 0.87 | ALDH1A1 (0.49) | ACE2ACEGPR34FOLH1MME | |
| SCHEMBL5870179 | 0.87 | ALDH1A1 (0.49) | ACE2ACEGPR34FOLH1MME | |
| SCHEMBL8249618 | 0.86 | ACE2 (0.51) | ACE2ACEGRNSORT1FOLH1 | |
| SCHEMBL5870524 | 0.86 | ACE2 (0.51) | ACE2ACEGRNSORT1FOLH1 | |
| SCHEMBL5869752 | 0.86 | PPARG (0.61) | ACE2ACEGPR34MMECPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |