Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 12/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477859 | 0.88 | MAPT (0.64) | NTRK1NTRK2MAPTMEN1KMT2A | |
| SCHEMBL7477058 | 0.88 | NTRK1 (0.66) | NTRK1NTRK2MAPTMEN1KMT2A | |
| SCHEMBL7478543 | 0.88 | NPC1 (0.52) | NTRK1NTRK2MAPTNPC1RAB9A | |
| SCHEMBL7489135 | 0.85 | BLM (0.52) | NTRK1NTRK2MAPTMEN1KMT2A | |
| SCHEMBL7479789 | 0.85 | NTRK1 (0.67) | NTRK1NTRK2MAPTMEN1KMT2A | |
| SCHEMBL7483515 | 0.75 | NPC1 (0.52) | NTRK1NTRK2MAPTMEN1KMT2A | |
| SCHEMBL7482437 | 0.72 | MAPT (0.53) | MAPTMEN1KMT2ATP53NPC1 | |
| SCHEMBL7426861 | 0.72 | MAPT (0.47) | NTRK1NTRK2MAPTMEN1KMT2A | |
| SCHEMBL7483095 | 0.71 | MAPT (0.67) | NTRK1NTRK2MAPTMEN1KMT2A | |
| SCHEMBL7426870 | 0.69 | NTRK1 (0.64) | NTRK1NTRK2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |