Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478240 | 0.90 | MAPT (0.51) | MAPTNPC1RAB9ATP53MEN1 | |
| SCHEMBL7482445 | 0.88 | MAPT (0.63) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL7474057 | 0.81 | MAPT (0.61) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL7477984 | 0.81 | MAPT (0.56) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL7476548 | 0.79 | MAPT (0.54) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL7478572 | 0.77 | MAPT (0.57) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL7480839 | 0.74 | GLS (0.55) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL7476148 | 0.73 | MAPT (0.61) | MAPTNPC1RAB9ATP53LMNA | |
| SCHEMBL7479785 | 0.73 | POLB (0.48) | MAPTNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL7425975 | 0.72 | NTRK1 (0.52) | MAPTNPC1RAB9AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |