SCHEMBL7426124

SCHEMBL7426124

Nc1cc(-c2ccc(Cl)cn2)cc2nc(-c3ccccn3)nn12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.51
L3MBTL1 Q9Y468 3/20 0.41
ADORA1 P30542 3/20 0.39
NPC1 O15118 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
HTT P42858 2/20 0.38
MAPT P10636 2/20 0.38
LMNA P02545 1/20 0.38
PPP1CA P62136 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
GRM5 P41594 4/20 0.38
PDE10A Q9Y233 1/20 0.37
KDM4E B2RXH2 2/20 0.37
CCR1 P32246 1/20 0.37
CCR5 P51681 1/20 0.37
CCR8 P51685 1/20 0.37
ALOX15 P16050 1/20 0.37
RAB9A P51151 2/20 0.36
ALDH1A1 P00352 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7428533 0.89 ADORA2A (0.60) ADORA2AL3MBTL1ADORA1NPC1SMN1; SMN2
SCHEMBL7705856 0.87 ADORA2A (0.54) ADORA2AL3MBTL1ADORA1NPC1SMN1; SMN2
SCHEMBL7485182 0.84 ADORA2A (0.49) ADORA2AL3MBTL1NPC1SMN1; SMN2HTT
SCHEMBL7428299 0.84 ADORA2A (0.53) ADORA2AL3MBTL1ADORA1NPC1SMN1; SMN2
SCHEMBL7434316 0.84 ADORA2A (0.48) ADORA2AL3MBTL1ADORA1NPC1SMN1; SMN2
SCHEMBL7703127 0.83 ADORA2A (0.52) ADORA2AL3MBTL1ADORA1NPC1SMN1; SMN2
SCHEMBL7426515 0.82 ADORA2A (0.51) ADORA2AL3MBTL1ADORA1NPC1SMN1; SMN2
SCHEMBL7542178 0.82 ADORA2A (0.52) ADORA2AL3MBTL1ADORA1NPC1SMN1; SMN2
SCHEMBL7708776 0.81 ADORA2A (0.53) ADORA2AL3MBTL1ADORA1NPC1SMN1; SMN2
SCHEMBL7708907 0.81 ADORA2A (0.52) ADORA2AL3MBTL1ADORA1NPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1214322-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-06-19 EP claimed
US-6355653-B1 DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS HOFFMANN-LA ROCHE INC. 2002-03-12 US claimed
WO-2001017999-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2001-03-15 WO claimed
EP-1214322-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-06-19 EP disclosed
US-6355653-B1 DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS HOFFMANN-LA ROCHE INC. 2002-03-12 US disclosed
WO-2001017999-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2001-03-15 WO disclosed