Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420140 | 0.91 | SLC22A12 (0.53) | SLC22A12ALOX5APKDM4ETP53RXFP1 | |
| SCHEMBL7417097 | 0.88 | SLC22A12 (0.43) | SLC22A12ALOX5APPOLBKDM4ELMNA | |
| SCHEMBL29611861 | 0.87 | ALOX5AP (0.47) | PLA2G2AALOX5APKDM4ETP53RXFP1 | |
| SCHEMBL687131 | 0.87 | ALOX5AP (0.47) | PLA2G2AALOX5APKDM4ETP53RXFP1 | |
| SCHEMBL7417850 | 0.86 | L3MBTL1 (0.40) | ALOX5APKDM4EMAPK1MAPTALOX5 | |
| Hydrochloric Acid SCHEMBL7477963 | 0.85 | L3MBTL1 (0.39) | ALOX5APKDM4EMAPK1MAPTALOX5 | |
| SCHEMBL7427199 | 0.85 | SLC22A12 (0.47) | PLA2G2ASLC22A12POLBKDM4ELMNA | |
| SCHEMBL3842264 | 0.84 | CNR2 (0.47) | ALOX5APKDM4EMAPTL3MBTL1 | |
| SCHEMBL7427533 | 0.83 | ALOX5AP (0.46) | SLC22A12ALOX5APTP53RXFP1ALOX5 | |
| SCHEMBL7707842 | 0.83 | ALOX5AP (0.45) | SLC22A12ALOX5APTP53RXFP1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |