Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.53 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426437 | 0.91 | PLA2G2A (0.44) | SLC22A12ALOX5APKDM4EALOX5LTC4S | |
| SCHEMBL7417097 | 0.89 | SLC22A12 (0.43) | SLC22A12ALOX5APKDM4EALDH1A1HPGD | |
| SCHEMBL7427533 | 0.86 | ALOX5AP (0.46) | SLC22A12ALOX5APALDH1A1ALOX5LTC4S | |
| SCHEMBL7707842 | 0.85 | ALOX5AP (0.45) | SLC22A12ALOX5APALDH1A1ALOX5LTC4S | |
| SCHEMBL7417850 | 0.85 | L3MBTL1 (0.40) | ALOX5APKDM4EALDH1A1ALOX5LTC4S | |
| SCHEMBL3842264 | 0.85 | CNR2 (0.47) | ALOX5APKDM4EALDH1A1 | |
| SCHEMBL7424721 | 0.84 | SLC22A12 (0.57) | SLC22A12ALOX5APKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7477963 | 0.84 | L3MBTL1 (0.39) | ALOX5APKDM4EALDH1A1ALOX5LTC4S | |
| SCHEMBL687131 | 0.83 | ALOX5AP (0.47) | ALOX5APKDM4EALDH1A1DPP4TP53 | |
| SCHEMBL7420327 | 0.83 | ALOX5AP (0.46) | ALOX5APKDM4EDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |