Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763205 | 0.84 | HDAC2 (0.53) | SMN1; SMN2HDAC1HDAC3HDAC2RAB9A | |
| SCHEMBL740382 | 0.83 | HDAC3 (0.68) | SMN1; SMN2HDAC1HDAC3HDAC2GAA | |
| SCHEMBL5554898 | 0.80 | RAB9A (0.72) | RAB9ALMNATP53POLBKMT2A | |
| SCHEMBL5554906 | 0.80 | RAB9A (0.72) | RAB9ALMNATP53POLBKMT2A | |
| SCHEMBL27178847 | 0.79 | KMT2A (0.49) | SMN1; SMN2HDAC1HDAC3HDAC2LMNA | |
| SCHEMBL27178877 | 0.79 | KMT2A (0.49) | SMN1; SMN2HDAC1HDAC3HDAC2LMNA | |
| SCHEMBL26986347 | 0.78 | RAB9A (0.55) | RAB9AGAALMNAPOLBKMT2A | |
| SCHEMBL27136774 | 0.78 | RAB9A (0.55) | RAB9AGAALMNAPOLBKMT2A | |
| SCHEMBL739285 | 0.76 | HDAC2 (0.60) | SMN1; SMN2HDAC1HDAC3HDAC2RAB9A | |
| SCHEMBL739286 | 0.76 | HDAC2 (0.60) | SMN1; SMN2HDAC1HDAC3HDAC2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |