Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 7/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043416 | 0.78 | BRD4 (0.36) | BRD4CREBBPPRKCICYP2A6GAA | |
| SCHEMBL18683804 | 0.74 | PRKCI (0.60) | BRD4CREBBPPRKCICYP2A6PIK3CB | |
| SCHEMBL7415949 | 0.72 | AR (0.40) | ARPRKCICYP2A6PIK3CBMAPT | |
| SCHEMBL12965849 | 0.72 | AR (0.45) | BRD4CREBBPARGAALMNA | |
| SCHEMBL12965982 | 0.70 | AR (0.44) | BRD4CREBBPARGAALMNA | |
| SCHEMBL7420662 | 0.70 | MAPT (0.44) | PRKCICYP2A6PIK3CBGAALMNA | |
| SCHEMBL13881963 | 0.69 | LMNA (0.44) | BRD4CREBBPARGAALMNA | |
| SCHEMBL28379496 | 0.69 | CA9 (0.44) | BRD4CREBBPCYP2A6MAPTALDH1A1 | |
| SCHEMBL18873365 | 0.68 | PRKCI (0.46) | PRKCICYP2A6PIK3CBMAPTSMN1; SMN2 | |
| SCHEMBL26569894 | 0.68 | PRKCI (0.58) | PRKCICYP2A6PIK3CBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656003-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |