SCHEMBL7415949

SCHEMBL7415949

Cn1ccc2cc3c(cc21)CCN3

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.40
DRD2 P14416 1/20 0.40
DRD4 P21917 1/20 0.40
PRKCI P41743 1/20 0.40
CYP2A6 P11509 2/20 0.37
PIK3CB P42338 1/20 0.37
MAPT P10636 3/20 0.36
NPC1 O15118 2/20 0.36
HTR2C P28335 2/20 0.36
RAB9A P51151 2/20 0.36
CYP3A4 P08684 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
TP53 P04637 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
PKM P14618 1/20 0.36
HTR2A P28223 1/20 0.36
MAPK1 P28482 1/20 0.36
CHRNA7 P36544 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7420662 0.90 MAPT (0.44) PRKCICYP2A6PIK3CBMAPTNPC1
SCHEMBL7420307 0.80 AR (0.36) ARDRD2DRD4HTR2CHTR2A
SCHEMBL7417887 0.80 AR (0.37) ARDRD2DRD4MAPTCYP3A4
SCHEMBL9919051 0.78 AR (0.45) ARDRD2DRD4MAPTMEN1
SCHEMBL28379496 0.76 CA9 (0.44) DRD2DRD4CYP2A6MAPTNPC1
SCHEMBL18683804 0.75 PRKCI (0.60) PRKCICYP2A6PIK3CBMAPTKDM4E
SCHEMBL7468196 0.73 AR (0.43) ARDRD2DRD4MAPTNPC1
SCHEMBL18873365 0.73 PRKCI (0.46) PRKCICYP2A6PIK3CBMAPTNPC1
SCHEMBL7426538 0.72 BRD4 (0.44) ARPRKCICYP2A6PIK3CBMAPT
SCHEMBL7422651 0.69 AR (0.42) ARDRD2DRD4MAPTCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0743946-A1 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES SMITHKLINE BEECHAM PLC (GB) 1996-11-27 EP disclosed
WO-1996011929-A1 BIHETEROARYL-CARBONYL AND CARBOXAMIDE DERIVATIVES WITH 5HT 2C/2B ANTAGONISTS ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1996-04-25 WO disclosed
WO-1995021844-A1 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES SMITHKLINE BEECHAM PLC (GB) 1995-08-17 WO disclosed
EP-0656003-A1 CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-06-07 EP disclosed
WO-1994004533-A1 CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-03-03 WO disclosed