Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.53 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12879321 | 1.00 | LMNA (0.55) | LMNASMN1; SMN2SLC1A3SLC1A1HTT | |
| SCHEMBL5019077 | 0.86 | LMNA (0.59) | LMNASMN1; SMN2SLC1A3SLC1A1HTT | |
| SCHEMBL7431205 | 0.85 | SLC1A3 (0.64) | LMNASMN1; SMN2SLC1A3SLC1A1HTT | |
| SCHEMBL10705141 | 0.83 | SLC1A1 (0.65) | LMNASMN1; SMN2SLC1A3SLC1A1HTT | |
| SCHEMBL29398484 | 0.83 | SLC1A3 (0.58) | LMNASMN1; SMN2SLC1A3SLC1A1HTT | |
| SCHEMBL7375139 | 0.83 | SLC1A1 (0.65) | LMNASMN1; SMN2SLC1A3SLC1A1HTT | |
| SCHEMBL4431806 | 0.83 | LMNA (0.56) | LMNASMN1; SMN2SLC1A3SLC1A1HTT | |
| SCHEMBL15317909 | 0.83 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2HTTCTSLCTSS | |
| SCHEMBL13569333 | 0.83 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2HTTCTSLCTSS | |
| SCHEMBL4430839 | 0.83 | LMNA (0.56) | LMNASMN1; SMN2SLC1A3SLC1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640242-B1 | ROCK-INHIBITING COMPOUND AND USES THEREOF | HITGEN LTD (CN) | 2023-04-19 | — | — | EP | disclosed |
| US-11078161-B2 | Rock-inhibiting compound and uses thereof | HITGEN INC. (CN) | 2021-08-03 | — | — | US | disclosed |
| CN-109134433-B | Compound for inhibiting ROCK and application thereof | 成都先导药物开发股份有限公司 | 2021-05-25 | — | — | CN | disclosed |
| CN-109134367-B | Compound for inhibiting ROCK and application thereof | 成都先导药物开发股份有限公司 | 2020-10-02 | — | — | CN | disclosed |
| US-20200190035-A1 | ROCK-INHIBITING COMPOUND AND USES THEREOF | HITGEN INC. (CN) | 2020-06-18 | — | — | US | disclosed |
| EP-3640242-A1 | ROCK-INHIBITING COMPOUND AND USES THEREOF | Hitgen Ltd. (CN) | 2020-04-22 | — | — | EP | disclosed |
| US-4709032-A | VASODILATION AND HYPOTENSIVE AGENT | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1987-11-24 | — | — | US | disclosed |
| US-4634770-A | VASODILATORS, HYPOTENSIVES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1987-01-06 | — | — | US | disclosed |
| US-4560755-A | VASODILATOR, HYPOTENSOR | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-12-24 | — | — | US | disclosed |
| US-4525589-A | Isoquinolinesulfonyl derivatives | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-06-25 | — | — | US | disclosed |
| EP-0061673-B1 | ISOQUINOLINESULFONYL DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-10-24 | — | — | EP | disclosed |
| US-4456757-A | MUSCLE RELAXANTS, VASODILATORS, HYPOTENSIVE AGENTS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1984-06-26 | — | — | US | disclosed |
| EP-0109023-A1 | Isoquinolinesulfonamide derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-05-23 | — | — | EP | disclosed |
| EP-0061673-A1 | Isoquinolinesulfonyl derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078161-B2 | Rock-inhibiting compound and uses thereof | ROCK1, ROCK2, RHOA | LMNA 2263/4885SMN1; SMN2 3309/4885SLC1A3 3256/4885 |
| US-20200190035-A1 | ROCK-INHIBITING COMPOUND AND USES THEREOF | ROCK1, ROCK2, RHOA | LMNA 2263/4885SMN1; SMN2 3309/4885SLC1A3 3256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.