Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GRN | P28799 | 2/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | PTGFR | P43088 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430645 | 0.90 | GRN (0.44) | MAPK1GRNSORT1 | |
| SCHEMBL7419986 | 0.89 | MAPK1 (0.48) | MAPK1GRNSORT1ADRB3ADRB1 | |
| SCHEMBL7419023 | 0.78 | GRN (0.47) | MAPK1GRNSORT1CYP2C9CYP2C19 | |
| SCHEMBL7421897 | 0.78 | NR4A2 (0.49) | MAPK1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7424536 | 0.77 | MAPK1 (0.42) | MAPK1GRNSORT1MEN1KMT2A | |
| SCHEMBL7422599 | 0.76 | GRN (0.47) | MAPK1GRNSORT1PTGFR | |
| SCHEMBL7424624 | 0.71 | GRN (0.44) | MAPK1GRNSORT1MEN1KMT2A | |
| SCHEMBL5869850 | 0.71 | ACE2 (0.53) | MAPK1GRNSORT1HTRA1 | |
| SCHEMBL5869853 | 0.71 | ACE2 (0.53) | MAPK1GRNSORT1HTRA1 | |
| SCHEMBL5869860 | 0.71 | ACE2 (0.53) | MAPK1GRNSORT1HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |