Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGFR | P43088 | 3/20 | 0.41 |
| ▸ | GRN | P28799 | 2/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430645 | 0.94 | GRN (0.44) | MAPK1GRNSORT1FOLH1LMNA | |
| SCHEMBL7426737 | 0.89 | MAPK1 (0.41) | MAPK1MEN1KMT2APTGFRGRN | |
| SCHEMBL7421897 | 0.86 | NR4A2 (0.49) | MAPK1 | |
| SCHEMBL7419023 | 0.82 | GRN (0.47) | MAPK1GRNSORT1FOLH1LMNA | |
| SCHEMBL7422599 | 0.82 | GRN (0.47) | MAPK1PTGFRGRNSORT1LMNA | |
| SCHEMBL7424536 | 0.80 | MAPK1 (0.42) | MAPK1MEN1KMT2AGRNSORT1 | |
| SCHEMBL7378949 | 0.79 | MME (0.50) | FOLH1LMNAALDH1A1 | |
| SCHEMBL7424457 | 0.78 | NR4A2 (0.48) | MAPK1MEN1KMT2AGRNSORT1 | |
| SCHEMBL7427491 | 0.77 | ENPP2 (0.45) | MAPK1 | |
| SCHEMBL5870478 | 0.77 | MAPK1 (0.55) | MAPK1GRNSORT1FOLH1HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |